Thy-1mutant mouse lymphoma cells of the class E complementation group are unable to synthesize the normal GlclManBGlcNAcz lipid-linked oligosaccharide, but instead accumulate a smaller lipid-linked species with the structure Manal -+ 2Manal 3 tMana1 -+ 3(Manal+ G)Ma*l-+ 4GlcNAc/?l+ 4GlcNAc (Trowbridge, I., and Hyman, R. (1979) Cell 17, 503-508 and Chapman, A., Trowbridge, I., Hyman, R., and Kor...

results apoptosis induced by pa in ins-1 cells was significantly resolved after liraglutide treatment. simultaneously, autophagy was enhanced with the treatment of pa and liraglutide. conclusions: liraglutide appears to protect ins-1 cells from apoptosis ffa-induced by promoting autophagy. conclusions these findings provide a novel role for glp-1 analogue in preventing or treating with t2d. obj...

III .6(1cells exhibiting a 140-fold increase in resistance to vincristine contain three surface membrane proteins with molecular weights of 210,000 (P210), 180,000 (HISO), and 150,000 (P150) which are highly phosphorylated in vivo and in an in vitro system in the presence of Mn2* and IT-^PJATP. These phosphorylated proteins are either absent or present in very low levels in membranes of drug-se...

1.121(1cells treated with 1 HIM6-azauridine (A/I nl) (concentration causing 50% inhibition of cell growth, 3 MM)continued to divide at a reduced rate for 72 h before stopping. However, a 24-h treatment was lethal to 99% of the cells, as determined by colony formation. To investigate the mechanism for this delayed cytotoxicity, the metabolism of A/I nl was studied. Cells incubated with AzUrd con...

We have previously shown a delay of death by lymphoma in SJL/J mice irradiated with continuous very low doses of ionizing radiation. In order to understand the mechanisms involved in this phenomenon, we have irradiated in vitro the Raw264.7 monocytic and the YAC-1 lymphoma cell lines at very low-dose rate of 4cGy.month(-1). We have observed a transient increase in production of both free radica...

The mode of action of the antiproliferative nucleoside analogue 2,6diaminopurinedeoxyriboside (DAPdR) has been characterized in cultured 11210 cells. A marked concentration-dependent decrease in DNA syn thesis and ribonucleotide reductase activity occurred in LI 210 cells exposed to 0.05 to 1.0 HIM DAPdR. Concomitantly, dGTP levels in creased as much as 1100-fold as compared to untreated contro...

Recent studies have shown promising results concerning the effectiveness of 3D plates in terms of stabilization of condylar fractures. Despite the use of new techniques and new materials, we can still observe certain side effects, including the immune reaction of the body, which may lead to the excessive inflammation. The aim of this paper was to determine how the production of prostaglandin E₂...