نتایج جستجو برای: 2 receptor gamma chain

تعداد نتایج: 3228676  

Journal: :iranian journal of allergy, asthma and immunology 0
maryam nourizadeh immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran. stephan borte division of clinical immunology, department of laboratory medicine, karolinska university hospital huddinge, stockholm, sweden and jeffrey modell diagnostic and research center for primary immunodeficiencies, municipal hospital st. georg, leipzig, germany. mohammadreza fazlollahi immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran. lennart hammarström division of clinical immunology, department of laboratory medicine, karolinska university hospital huddinge, stockholm, sweden. zahra pourpak immunology, asthma and allergy research institute, tehran university of medical sciences, tehran, iran.

severe combined immunodeficiency (scid) represents a rare group of primary immunodeficiency disorders (pids), with known or unknown genetic alterations. here, we report a new interleukin 2 receptor, gamma chain (il-2rg) mutation in an iranian scid newborn.the patient was a 6-day old boy with a family history of pid. the child was screened using a molecular-based analysis for the assessment of t...

Journal: :Molecular and cellular biology 1996
E A Bach J W Tanner S Marsters A Ashkenazi M Aguet A S Shaw R D Schreiber

Functionally active gamma interferon (IFN-gamma) receptors consist of an alpha subunit required for ligand binding and signal transduction and a beta subunit required primarily for signaling. Although the receptor alpha chain has been well characterized, little is known about the specific role of the receptor beta chain in IFN-gamma signaling. Expression of the wild-type human IFN-gamma recepto...

Journal: :The Journal of Experimental Medicine 1994
T Nakarai M J Robertson M Streuli Z Wu T L Ciardelli K A Smith J Ritz

The interleukin 2 receptor (IL-2R) is known to be comprised of at least three genetically distinct subunits termed alpha, beta, and gamma. These chains can be expressed individually or in various combinations resulting in distinct receptors with different affinities for IL-2. In contrast to alpha and beta, the cell surface expression of the gamma chain protein previously has not been well-chara...

Journal: :Blood 1995
I E Van den Herik-Oudijk M W Ter Bekke M J Tempelman P J Capel J G Van de Winkel

Most Ig receptors exist as multi-subunit complexes with a unique ligand binding alpha chain and a common signaling FcR gamma-chain. The myeloid Fc gamma RIIa (CD32) appears unique among FcR because both ligand-binding and signaling capacity are found in the alpha chain. Within the cytoplasmic tails of Fc gamma RIIa and FcR gamma-chain similar, but not identical, activatory motifs (ITAMs) have b...

Journal: :Blood 1995
S Kumaki H D Ochs M Timour K Schooley M Ahdieh H Hill K Sugamura D Anderson Q Zhu D Cosman

X-linked severe combined immunodeficiency (XSCID) is characterized by absent or profoundly reduced numbers of T cells and normal numbers of B cells in the circulation. Affected patients have mutations of the interleukin-2 (IL-2) receptor gamma chain gene. Using Epstein-Barr virus-transformed B-lymphoblastoid cell lines (B-LCLs) established from two unrelated XSCID patients, we could show that n...

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