N25, a novel histone deacetylase inhibitor, was created through structural modification of suberoylanilide hydroxamic acid. To evaluate the anti-tumor activity of N25 and clarify its molecular mechanism of inducing autophagy in glioma cells, we investigated its in vitro anti-proliferative effect and in vivo anticancer effect. Moreover, we detected whether N25 induces autophagy in glioma cells b...

UNLABELLED Macrophages in liver tissue are widely defined as important inflammatory cells in chronic viral hepatitis due to their proinflammatory activity. We reported previously that interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) play significant roles in causing chronic hepatitis in hepatitis C virus (HCV) transgenic mice (S. Sekiguchi et al., PLoS One 7:e51656, 2012, http://dx....

Current therapies for gliomas often fail to address their infiltrative nature. Conventional treatments leave behind small clusters of neoplastic cells, resulting in eventual tumor recurrence. In the present study, we have evaluated the antitumor activity of neural progenitor cells against gliomas when stereotactically injected into nucleus Caudatus of Fisher rats. We show that the rat neural pr...

Current therapies for gliomas often fail to address their infiltrative nature. Conventional treatments leave behind small clusters of neoplastic cells, resulting in eventual tumor recurrence. In the present study, we have evaluated the antitumor activity of neural progenitor cells against gliomas when stereotactically injected into nucleus Caudatus of Fisher rats. We show that the rat neural pr...

Chronic hepatitis C, which is caused by infection with the hepatitis C virus (HCV), is a global health problem. Using a mouse model of hepatitis C, we examined the therapeutic effects of a recombinant vaccinia virus (rVV) that encodes an HCV protein. We generated immunocompetent mice that each expressed multiple HCV proteins via a Cre/loxP switching system and established several distinct atten...

Our objective was to understand how mineral N availability alters accumulation of N reserves (nitrate, amino acids, soluble proteins and vegetative storage proteins known as VSP) in alfalfa (Medicago sativa L. cv Lodi) taproots. The effects of variation in NH4NO3 availability were followed by studying non-nodulated plants grown under hydroponic conditions during 21 days with (i) different N sup...

Article history: Received 11 December 2008 Received in revised form 25 August 2009 Accepted 21 September 2009 Available online 15 October 2009 Using data from prewar Japan, this paper investigates the impact of a liquidity shock induced by depositors' behavior on bank portfolio management during financial crises in a system lacking deposit insurance. It is found that banks reacted to the liquid...

• Biochar and digestate were tested as novel sorbents for biopurification systems. • Digestate and biochar mixture enhanced the sorption coefficient by a factor of N50. • Boscalid and pyrimethanil exhibited N25 fold higher Kd/Koc values than bentazone. • Desorption was hysteretic (H ≥ 0.001) for biochar and digestate based soil

Abstract Late Cenozoic was a period of large-scale extension in the Aegean. The is mainly recorded metamorphic core complexes with little data from sedimentary sequences. exception Thrace Basin northern Aegean, which has continuous record Middle Eocene to Oligocene marine sedimentation. In Basin, Oligocene–Early Miocene characterized by north-northwest (N25°W) shortening leading termination sed...

The deployment of endovascular implants such as stents in the treatment of cardiovascular disease damages the vascular endothelium, increasing the risk of thrombosis and promoting neointimal hyperplasia. The rapid restoration of a functional endothelium is known to reduce these complications. Circulating endothelial progenitor cells (EPCs) are increasingly recognized as important contributors t...