Histone deacetylase (HDAC) inhibitors and tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) show promise for the treatment of cancers. The purpose of this study was to examine the molecular mechanisms by which HDAC inhibitor MS-275 sensitizes TRAIL-resistant breast cancer cells in vivo, inhibits angiogenesis andmetastasis, and reverses epithelial-mesenchymal transition (EMT). BALB...

adaptive clustering, 235 adaptive resonance theory (ART), 221, 242 ADIT, 135 comparison, 135–136, 145 aging, 222 ALCOVE, 129–132, 275, 278 comparison, 34, 78, 112, 136, 143–145, 229, 231, 241, 244, 275 Anderson, J. R., 5, 173, 176, 180, 182, 242, 301 angle categorization, 33 anterior cingulate, 8, 68, 70, 215 anterior striatum, 8 ARACHNE , 269 artificial concepts, 325, 327 Asch, S., 329 Ashby, ...

1 Introduction 1.1 Wh-expressions as diagnostics of scope 1.1.1 Fronting and possible answers as indicators of scope 1.1.2 3 Subjacency and wh-in-situ 3.1 The diagnostic of possible answers 3.

Splenectomy indications and outcome were evaluated in 124 adults with hemoglobin SC disease (Hb SC). Twelve patients (9.6%) required splenectomy. There was a significant difference between the splenectomy group and the non-splenectomy group, respectively, regarding Hb levels (median 7.2 g/dL vs. 12.5 g/dL, P < 0.0001), platelet counts (median 146 x 10(6)/L vs. 275 x 10(6)/L, P = 0.031), palpabl...

natural rubber/fiber composites were prepared in a laboratory mixer using new and waste short nylon fiber by a one-step mixing process. fiber loading and bonding agent effects on the microstructure and mechanical properties of the composites were studied. the cure characteristics of composites were investigated by using rheometer. cure and scorching times of the composites decreased while maxim...

In many prokaryotes and eukaryotes, DNA methylation at cis-regulatory sequences determines whether gene expression is on or off. Stable inheritance of these expression states is required in bacterial pathogenesis, cancer and developmental pathways1,2. Here we delineate the factors that control the stability of these states by using the agn43 gene in Escherichia coli as a model system. Systemati...