In recent years, the diagnostic and therapeutic uses of radioisotopes have shown significant progress. Immunoglobulin (Ig) appears to be a promising tracer, particularly due to its ability to target selected antigens. The main objective of this study is to optimize and assess an Ig radiolabeling method with Technetium 99m (99mTc), an attractive radioelement used widely for diagnostic imaging. M...

Pyrroloquinoline quinone (PQQ), an essential nutrient, antioxidant, redox modulator and nerve growth factor found in a class of enzymes called quinoproteins, was labeled with 99mTc by using stannous fluoride (SnF2) method. Radiolabeling qualification, quality control and characterization of 99mTc-PQQ and its biodistribution studies in mice were performed and discussed. Effects of pH values, tem...

Thalidomide is a sedative drug discovered at the end of 50s, it showed high anticancer activity so attempts were made to synthesize thalidomide analogs that had fewer side effects than parent compound. DPDQA higher activities thalidomide. Labeling with 99mTc using Na2S2O4 as reducing agent was performed. The dependence radiolabeling yield on concentrations and agent, pH reaction mixture, time, ...

Due to large homology of human and canine EGFR, dogs suffering from spontaneous EGFR+ cancer can be considered as ideal translational models. Thereby, novel immunotherapeutic compounds can be developed for both human and veterinary patients. This study describes the radiolabeling of a canine anti-EGFR IgG antibody (can225IgG) with potential diagnostic and therapeutic value in comparative clinic...

Bombesin (BN) is a peptide exhibiting a high affinity for the gastrin-releasing peptide (GRP) receptor, which is overexpressed by a variety of tumors, including breast or prostate cancer. The aim of the present study was the investigation of the complexes formed between a series of BN-like peptides and the nuclides (185/187)Re and 99mTc. The (185/187)Re complexes were formed via the precursor R...

introduction bacterial infection is one of the major causes of morbidity and mortality especially in developing countries. nuclear medicine has an important role in helping the diagnosis of deep-seated infections by developing more specific radiopharmaceuticals. the aim of this study was to evaluate 99mtc-labeling ceftriaxone as a new radiopharmaceutical for staphylococcus aureus infection imag...

The use of radiolabeled antibiotics as diagnostic agents is an emerging area of medical research. Vibramycin is a semisynthetic antibiotic of the tetracycline family prescribed to treat a variety of infections. We present in this study a new technetium-99m labeled vibramycin radiopharmaceutical using SnCl2.2H2O as a reducing agent. The stability of 99mTc-vibramycin was evaluated in human serum ...

Imaging of infection and inflammation is an important issue in nuclear medicine as it may have relevant implication for the management of patients with infections or inflammatory diseases. In this regard the synthesis of human polyclonal immunoglobuline G (IgG) radiolabeled with technetium-99m (99mTc) by a novel method, via a nicotinamide hydrazine derivative, was performed. The biologica...

The diaminodithiol (DADT) ligand has been conjugated to the neuromuscular blocking agent benzovesamicol (BVM) in the 5-position. DADT-BVM 1 was synthesized by coupling of 5-aminomethylbenzovesamicol with a BCA thiolactone reagent. 99mTc radiolabeling of 1 with [99mTc]glucoheptonate gave a 4.7:1 mixture of two 99mTc complexes as determined by HPLC. Biodistribution data of the major [99mTc]-1 com...