background: acute myeloid leukemia (aml) is known as one of the most common leukemia among adults. environmental and different genetic factors affect disease process, prognosis and treatment. among different genetic factors npm1, flt3, mll and baalc genes are the most effective on patient's survival rate. the aim of this study was to assess amount of baalc gene expression in aml patients, and i...

background: allogeneic hematopoietic stem cell transplantation (hsct) is a curative treatment option for many patients with acute myeloid leukemia (aml); however, it can lead to complications of graft-versus-host-disease (gvhd) which can affect the quality of life and overall survival. the aim of this study was to assess the effects of both acute and chronic gvhd on survival rate in patients wi...

acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. the conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. it has been rarely reported in the literature. in leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. herein, we rep...

introduction: acute myeloid leukemia (aml) is a clonal disease characterized by heterogeneous involvement of hematopoietic bone marrow cell populations. in aml patients, a variety of clinical and biologic parameters, including surface markers, have been examinedfor potential value in predicting treatment response and survival. by checking the myeloid, lymphoid and nonspecific markers on the bla...

Acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. The conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. It has been rarely reported in the literature. In leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. Herein, we rep...

Background & Objective:  Zataria multiflora is a plant that belongs to Laminaceae family. It is traditionally believed to have several therapeutic effects. Acute promyelocytic leukemia is a distinct subtype of acute myeloid leukemia with dominancy of promyelocytes in bone marrow and blood stream. The aim of this study is to investigate the anticancer effects of Z. multiflora extract on acute pr...

Background: Arsenic trioxide is a chemical compound that has been used as treatment for various diseases. Despite being potentially toxic, this therapy to treat Acute Myeloid Leukemia and investigated possible different types of cancer. Objectives: The present review aims describe the use studies reported in literature Trioxide therapeutic agent Leukemia, Promyelocytic Chronic Multiple Myeloma,...

background: the secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (pml-rara) fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 (fms-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. however, the prognostic significance of flt3 mutat...

Background: The secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (PML-RARA) fusion gene may contribute to the acute promyelocytic leukemogenesis. Chromosomal alterations and mutation of FLT3 (FMS-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. However, the prognostic significance of FLT3 mutat...