the anti-ischemic effect of aqueous and ethanolic extracts of nigella sativa l. seed was studied using a four-vessel occlusion model in rats. the ischemia was evaluated by optical and transmission electron microscopy. after 20 min of forebrain ischemia, agents were administered intraperitoneally after reperfusion. both extracts comprised an alkaloid. in ischemic rats, the aqueous (1 g/kg) and e...

seaweeds have caused an emerging interest in the biomedical area, mainly due to their contents of bioactive substances which show great potential as anti-inflammatory, anti-microbial, anti-viral and anti-tumoral drugs. despite the diversity in quality and quantity of the mediterranean tunisian coast flora, with its large contains of marine organisms and seaweeds, most of them have not yet been ...

This review summarizes the data on anti-ischemic activity of carnosine. The pronounced anti-ischemic effects of carnosine in the brain and heart are due to the combination of antioxidant and membrane-protecting activity, proton buffering capacity, formation of complexes with transition metals, and regulation of macrophage function. In experimental cerebral ischemia, carnosine decreases mortalit...

Objective(s): Black cumin (Nigella sativa) belonging to Ranunculaceae family has a long history of medicinal use in various folk and traditional systems of medicine, including Iranian traditional medicine (ITM). These valuable medicinal seeds have been used traditionally against a variety of diseases such as dyspepsia, diabetes, headache, influenza and asthma. In addition, several scientific in...

The quinolone analog SQ-4004 has been identified as a potentially excellent anti-ischemic agent, which exhibited highly potent efficacy in reducing infarct volume size in vivo rat MCAO model (32.1% at 0.01mg/kg) and potent cardioprotective effect at myocardial infarction in vivo model (26.6% at 0.01mg/kg) while it exhibited highly reduced anti-bacterial activity. The mechanistic study revealed ...

a new series of transition metal complexes of co(ii), ni(ii), cu(ii) and zn(ii), has beensynthesized from the knoevenagel condensate schiff base ligand(l) derived from β-ketoanilideand furfural with o-phenylenediamine and diethylmalonate. structural features were determinedby spectral and analytical techniques. square-planar geometry has been adopted by thecomplexes except cobalt complex which ...

Recently, we reported that the A3 adenosine receptor (A3AR) agonist LJ529 (2-chloro-N(6)-(3-iodobnzyl)-5'-N-methylcarbamoyl-4'-thioadenosine) reduces cerebral ischemic injury via inhibition of recruitment of peripheral inflammatory cells into ischemic brain lesion. A3AR agonists, however, are known to possess anti-platelet activity, which may deter the combination therapy with tissue plasminoge...

actinomycetes were isolated from marine sediment samples collected from the east coast of chennai, tamil nadu, india. well diffusion and agar plug methods were used for the evaluation of antibiotic production by these isolates against drug resistant methicillin- resistant staphylococcus aureus (mrsa) and vancomycin resistant enterococci (vre). the potential isolate vitbrk2 was mass cultured for...