Antimicrobial preservatives are excipients added to multi-dose containers of both sterile and non-sterile drug products. Antimicrobial preservatives are used primarily to inhibit growth of microbial contamination occurring during the period of use. Demonstration of antimicrobial preservative effectiveness is required for these functional excipients. This article reviews key factors for consider...

Background & Aim:Nowadays, the use of chemical preservatives has been limited due to the controversial adverse effects. In this study, we evaluated the preservative potency of product with active herbal ingredients (Barij Baby cream) in contrast with the same products with two different chemical preservatives including methylparaben plus propylparaben and potassium sorbate plus...

Background & Aim:Nowadays, the use of chemical preservatives has been limited due to the controversial adverse effects. In this study, we evaluated the preservative potency of product with active herbal ingredients (Barij Baby cream) in contrast with the same products with two different chemical preservatives including methylparaben plus propylparaben and potassium sorbate plus...

disk diffusion test is the usual applicable method for assessing the antimicrobial susceptibility pattern in most institutions and hospitals. the aim of this study was to determine the reliability of resistant-reported results of disk diffusion test for 6 routinely used antibiotics against gram-positive microorganisms of nosocomial origin, using e-test method.    over a 1-year period, clinical ...

The antimicrobial effectiveness test first appeared as a USP General Chapter in the 18th revision, official September 1, 1970. This chapter, at the beginning, was designed to evaluate the performance of antimicrobials added to inhibit the growth of microorganisms that might be introduced during or subsequent to the manufacturing process. As Good Manufacturing Practices (GMPs) became a governing...

background: to evaluate the antimicrobial efficacy of four different hand sanitizers against staphylococcus aureus, staphylococcus epidermidis, pseudomonas aeruginosa , escherichia coli , and enterococcus faecalis as well as to assess and compare the antimicrobial effectiveness among fou different hand sanitizers. materials and methods: the present study is an in vitro study to evaluate antimic...

This study compared the antimicrobial effectiveness of nine dental materials and a negative control agent against 21 strains or species of bacteria using an agar diffusion assay. The materials were: 1. Camphorated parachlorophenol mixed with calcium hydroxide (CPC + Ca(OH)2). 2. CPC mixed with zinc oxide (CPC + ZnO). 3. Formocresol mixed with zinc oxide and eugenol (FC + ZOE). 4. Chlorhexidine ...

A method has been presented for evaluating the effectiveness of fabrics treated with antimicrobial agents to resist growth of contaminating organisms. The method consists of direct inoculation of the fabric with suitable test organisms and the subsequent enumeration of growing colonies which develop when the fabric is implanted in a nutrient medium. The method is sensitive, versatile, easy to p...