The structures of boron-doped fullerene B-C59 (1), as a drug delivery system (DDS), two phosphoramides (2 and 3), which are analogous to the cyclophosphamide anticancer prodrug, as well as their covalently bonded structures to B-C59 (4 and 5) were optimized by DFT computations at the B3LYP level of theory using 6-31G(d) basis set. Comparing compounds 4 and 5 revealed that the chloro derivative ...

The structures of boron-doped fullerene B-C59 (1) as a drug delivery system (DDS), two phosphoramides (2 and 3) which were analogous to the cyclophosphamide anticancer prodrug as well as their covalently bonded structures to B-C59 (4 and 5) were optimized by DFT computations at B3LYP level of theory using 6-31G(d) basis set. Comparing compounds 4 and 5 revealed that the chloro derivative (-1429...

Drug resistance is a major impediment to successful chemotherapy in pancreatic cancer (PC) patients. We investigated the effect of Wnt/β-catenin signaling inhibition by wnt-c59 on chemoresistance in a trichostatin A-resistant Panc-1 cell line (Panc-1/TSA). Panc-1/TSA cells were treated with the Wnt/β‑catenin signaling inhibitor wnt-c59 (10 µmol · l-1) and/or trichostatin A (TSA; 10 µmol · l-1) ...

Wnt/β-catenin signaling is responsible for the generation of cancer stem cells (CSCs) in many human tumors, including nasopharyngeal carcinoma (NPC). Recent studies demonstrate that Wnt or PORCN inhibitor, Wnt-C59, inhibits tumor growth in MMTV-WNT1 transgenic mice. The effect of Wnt-C59 in human tumors is not clear. In this study, the NPC cell lines investigated manifest heterogeneous response...

The molecular mechanisms of strain-specific probiotic effects and the impact of the oral administration of probiotic strains on the host's gene expression are not yet well understood. The aim of this study was to investigate the strain-specific effects of probiotic strain intake on gene expression in the murine small intestine. Two distinct strains of lactic acid bacteria, Lactobacillus rhamnos...

Porcupine (PORCN) is a membrane bound O-acyltransferase that is required for Wnt palmitoylation, secretion, and biologic activity. All evaluable human Wnts require PORCN for their activity, suggesting that inhibition of PORCN could be an effective treatment for cancers dependent on excess Wnt activity. In this study, we evaluated the PORCN inhibitor Wnt-C59 (C59), to determine its activity and ...

We give new simple general expressions for the asymptotic covariance of the estimated system parameters (A,B,C,D) in subspace identification. The formulas can be applied to a whole class of subspace methods including N4SID, MOESP, CVA etc. The asymptotic expressions highlight how the conditioning of the estimation problem influences the accuracy of the estimates. Journal of Economic Literature ...

Mixing SiOx materials with graphite has become a key technology to improve their performance, but it is still unclear what kind of help construct stable electrode structure. The purpose this study explore the effect morphology on structure and performance SiOx/C composite electrodes (850 mAh g−1). For SiOx/C59 constructed by lamellar (C59) big aspect ratio particles, particles agglomerate in po...

A novel nanocage structure derived from carboxymethyl-cyclodextrins (CMCDs) intercalated in layered double hydroxides (LDHs), whose gates can be controlled by the process of swelling/drying the CMCD-LDH, has been prepared. Furthermore, the extent of opening of this nanocage structure can be controlled by swelling in different solvents. Dodecylbenzene (DDB) as the guest molecule has been incorpo...

A novel coordination nanocage was obtained with in situ-generated tetrazole ligands from the cobalt-thiacalix[4]arene system. Four in situ-generated 1,3-bis(2H-tetrazol-5-yl)benzene ligands bolster eight Co4-calix shuttle-cock-like secondary building units (SBUs) into a hollow tetragonal prism with a high surface area. The unprecedented {Co32} nanocage presents the highest nuclearity example.