Epigenetic mechanisms such as DNA methylation are part of an emerging story on how early-life experiences can alter behavioral trajectories and lead to the development of disease and psychological disorders. Previous work from our laboratory has demonstrated alterations in methylation of DNA associated with the brain-derived neurotrophic factor (bdnf) gene within the amygdala and hippocampus of...

Purpose: The development of sensitive and non-invasive biomarkers for the early detection CRC determination their role in individual stages CRC. Methods: MMP-9 expression serum tissue, BDNF plasma were detected using ELISA method. tissue also determined by immunohistochemical staining. Results: To assess balance between changes survival tumor progression, we compared BDNF/MMP-9 ratios tissues l...

background: the induction of brain-derived neurotrophic factor (bdnf) expression in the hippocampus has shown to play a role in the beneficial effects of resveratrol (rsv) on the learning and memory. the bdnf gene has a complicated structure with eight 5’ noncoding exons (i-ixa), each of which can splice to a common coding exon (ix) to form a functional transcript. estrogens increase levels of ...

background: it has been known that brain-derived neurotrophic factor (bdnf) is involved in neural survival and long term memory (ltm). here we hypothesized that bdnf as a potent neurotrophic factor might modulate amnestic effect induced by morphine. objectives: the aim of this study was to examine whether infusion of exogenous bdnf in the ca1 regions of the dorsal hippocampi could ameliorate me...

as the middle-aged in the society as well as stress-induced cognitive disorders and dementia are increasing, sport is identified as a suitable solution to prevent disorders in central nervous system. the aim of the present study was to compare the effects of 8 weeks of strength and endurance training on bdnf. for this purpose, 150 male wistar rats participated in endurance training (running wit...

Brain-derived neurotrophic factor (BDNF) is known to play a role in experience-dependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats. Such acute actions of BDNF suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cor...