uniaxial compressive strength (ucs) is one of the most significant factors on the stability of underground excavation projects. most of the time, this factor can be obtained by exploratory boreholes evaluation. due to the large distance between exploratory boreholes in the majority of geotechnical projects, the application of geostatistical methods has increased as an estimator of rock mass pro...

Uniaxial compressive strength (UCS) is one of the most significant factors on the stability of underground excavation projects. Most of the time, this factor can be obtained by exploratory boreholes evaluation. Due to the large distance between exploratory boreholes in the majority of geotechnical projects, the application of geostatistical methods has increased as an estimator of rock mass pro...

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the construction of underground tunnel plays a more and more important role in the development of big cities. one of the most important problems caused by the construction of the tunnel is that underground excavation will cause large settlement of the ground and buildings. previous studied showed the difference between numerical and experimental results. in this study the case study of niyayesh...

Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of AD patients and transgenic mice. The crystal structure of Abeta-bound ABAD shows substantial de...

Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to construct a fusion gene that can express the TRX1-A...

Amyloid beta (Aβ) binding alcohol dehydrogenase (ABAD) is a cellular cofactor for promoting (Aβ)-mediated mitochondrial and neuronal dysfunction, and cognitive decline in transgenic Alzheimer's disease (AD) mouse models. Targeting mitochondrial ABAD may represent a novel therapeutic strategy against AD. Here, we report the biological activity of small molecule ABAD inhibitors. Using in vitro su...