Background: Triphala, which is a combination of fruits Terminalia chebula, bellerica and Embilica officinalis generally recommended as herbal drug formulation in the Indian traditional medicine system.
 Study Design: To study in-silico inhibitory potential Triphala constituents against cytochrome P450 2E1 (CYP2E1) for prevention Thioacetamide-induced Hepatotoxicity
 Place Duration Stu...

Cytochrome P450 2E1 (CYP2E1) enzyme metabolically activates a large number of low molecular mass xenobiotics probably involved in gastric cancer incidence through activation of procarcinogens. North of Iran is amongst high incidence rate areas of gastric carcinoma where environmental carcinogenic compounds, including agricultural pesticides, are massively used. In this report, we quantitatively...

Abstract Background Drug metabolism is crucial to attaining the therapeutic index of any drug. The and elimination drugs are governed mainly by P-glycoprotein (P-gp) Cytochrome P450 (CYP). Paracetamol mostly used as analgesic antipyretic agent. paracetamol primarily via Glucuronidation sulphation at doses. About 5–10% metabolized CYP mediated pathway. 2E1 (CYP2E1) responsible for forming a toxi...

BACKGROUND CYP2E1 encodes an enzyme which is mainly involved in bioactivation of potential carcinogens such as N-nitrosamines. Polymorphisms in the gene have been reported to be associated with cancer. The aim of this study was to evaluate genotype distributions and allele frequencies of five CYP2E1 polymorphisms in Iran. MATERIALS AND METHOD Two hundred healthy individuals of an Iranian popu...

Cytochrome P450 2E1 (CYP2E1) is a key enzyme in the metabolic activation of many low molecular weight toxicants and also an important contributor to oxidative stress. A noninvasive method to monitor CYP2E1 activity in vivo would be of great value for studying the role of CYP2E1 in chemical-induced toxicities and stress-related diseases. In this study, a mass spectrometry-based metabolomic appro...

We investigated the effect of an albumin infusion on enzyme activity, expression level cytochrome P450 2E1 (CYP2E1), and oxidative stress in serum liver streptozotocin (STZ)-induced diabetic rats. The STZ treatment enhanced alanine aminotransferase aspartate activities rat compared with those untreated Treatment elevated catalytic activity CYP2E1, stress, decreased reducing potentials liver, su...

The cytochrome P450 mixed function oxidase enzymes are the major catalysts involved in drug metabolism. There are many forms of P450. CYP2E1 metabolizes many toxicologically important compounds including ethanol and is active in generating reactive oxygen species. Since several of the contributions in the common theme series "Role of CYP2E1 and Oxidative/Nitrosative Stress in the Hepatotoxic Ac...

BACKGROUND The CYP2E1 and GSTM1 genes encode metabolic enzymes that have key functions in drug modification and elimination. METHODOLOGY/PRINCIPAL FINDINGS We investigated the possible effects of CYP2E1 and GSTM1 polymorphisms in 71 leprosy patients and in 110 individuals from the general population. The GSTM1*0 null allele and INDEL CYP2E1*1D mutant genotypes were analyzed by conventional PC...