aim : this study aims to investigate some clinical and pathologic factors associated with the prognosis of patients with colon and rectum cancers separately. background : colorectal cancer is the most common cancer of the digestive system and also the fourth cause of cancer-related deaths around the world. different studies indicate that survival of patients with colorectal cancer has improved ...

gonadotropin releasing hormone (gnrh) plays a key role in reproduction. this decapeptide is synthesized and released by hypothalamus and induces the pituitary gonadotrop cells to release pituitary gonadotropin hormones. in some extrapituitary compartments gnrh and its receptor act as part of the autocrine regulatory system of cell proliferation. the anticancer activity of gnrh and its analogues...

background : breast cancer is one of the most frequent malignancies among iranian women. triple-negative breast cancer (tnbc) is referred to a type of breast cancer which three biomarkers of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (her2), are negative. materials and methods: in this case control study, immunohistopathologic data of patients with tn...

background: there are no data on familial aggregation of colorectal cancer (crc) in northeastern iran. the aim of this study was to determine the prevalence of early-onset crc and patients suspected for hereditary non-polyposis colorectal cancer (hnpcc) based on the clinical criteria in this area. materials and methods: documents were collected from two hospitals in mashhad regarding 326 inpati...

background: inflammatory breast cancer (ibc), a subgroup of locally advanced breast cancer (labc), is diagnosed based on clinical findings, and seems to be different from other types of labc. the purpose of this study was to compare clinicopathological characteristics and outcomes between inflammatory and non-inflammatory labc patients at breast cancer research center (bcrc), tehran, iran. meth...

background: exposure to endogenous hormones such as estrogen is known as a lifetime breast cancer (bc) risk factor. polymorphisms in genes that are involved in the steroidogenic process, such as cytochrome p450c17alpha ( cyp17) , affect individuals’ susceptibility to bc. in iran, the highest incident of bc is among young women. this study aimed to find prevalence of single nucleotide polymorphi...

objective(s): the aim of this study was to analyze detection rates and effectiveness of 18f-fluorodeoxyglucose positron emission tomography (fdg-pet) cancer screening program for prostate cancer in japan, which is defined as a cancer-screening program for subjects without known cancer. it contains fdg-pet aimed at detection of cancer at an early stage with or without additional screening tests ...

introduction: cauda equina secondary to metastatic follicular thyroid cancer of the lumbosacral area is a rare entity.   case report: we report an unusual case of a 52-year-old male who presented with backache, lower limb weakness, and perianal numbness. a ct-scan of the lumbosacral area showed an enhancing mass at the l4, l5 and s1 vertebrae. histopathology after excision revealed a metastatic...

introduction: prostate cancer is one of the most common cancers among males and the second factor resulting to death due to cancer among them.(1) the median age of its diagnosis is 65 years. the initial treatment includes androgen ablation or orchiectomy.(2, 3) in case of patient’s hormone refractory, chemotherapy would be substituted. the objective of this study is the consideration of intermi...