a new efficient method for the synthesis of carboacyclic nucleosides as biologically interesting compounds via aza-conjugate addition of pyrimidine nucleobases to a,β-unsaturated esters in the presence of catalytic amount of lioh.h2o (1.2-4.8 mol%) under microwave irradiation is described. this method affords the title compounds in good to excellent yields and in short reaction times.

abstract background and objective: highly active antiretroviral therapy (haart) can effectively prevent the progression of hiv-1 replication and increase life expectancy. there are numerous causes of treatment failure and the leading one is drug resistance. thus, we aimed to determine the hiv rt gene drug resistance mutations in patients treated with antiretroviral medications. material and met...

Michael addition of pyrimidine and purine nucleobases to substituted as well as unsubstituted α,β-unsaturated esters efficiently proceeds in the presence of catalytic amount of zinc oxide in ionic liquid 1-butyl-3-methylimidazolium bromide (ZnO/[bmim]Br) under microwave irradiation to afford carboacyclic nucleosides, as biologically important compounds, in good to excellent yields and in short ...

background tenofovir disoproxil fumarate (tdf) is a new effective treatment option for patients with chronic hepatitis b (chb). objectives to evaluate tdf efficacy in nucleos(t)ide analogues (nas)-naive iranian patients with chb. patients and methods the na-naive patients received tdf for at least six months. the primary endpoint was the proportion of patients achieving a complete virological r...

Front Cover. A new C-nucleoside with strongly pairing ethynylmethylpyridone base and 3'-azido-2',3'-dideoxyribose sugar dubbed 'AZW' was described. The image shows the structure of AZW against a backdrop AZT in dotted cloud representation. nucleoside inhibitory activity Herpes simplex virus type 1 (HSV1) as reported by Richert et al. their full paper at10.1002/cbdv.202000937.

michael addition of pyrimidine and purine nucleobases to substituted as well as unsubstituted α,β-unsaturated esters efficiently proceeds in the presence of catalytic amount of zinc oxide in ionic liquid 1-butyl-3-methylimidazolium bromide (zno/[bmim]br) under microwave irradiation to afford carboacyclic nucleosides, as biologically important compounds, in good to excellent yields and in short ...

Michael addition of pyrimidine and purine nucleobases to substituted as well as unsubstituted α,β-unsaturated esters efficiently proceeds in the presence of catalytic amount of zinc oxide in ionic liquid 1-butyl-3-methylimidazolium bromide (ZnO/[bmim]Br) under microwave irradiation to afford carboacyclic nucleosides, as biologically important compounds, in good to excellent yields and in short ...