objective: cardiac cell differentiation with the help of mirnas has recently opened a promising window for the restoration of myocardial infarction. independent mir-1-2/133a-1 and mir-206/133b clusters are known to be expressed in cardiac and skeletal muscles, respectively. mir-133b differs from mir-133a by only one nucleotide. the sequence similarity of these two mirnas suggests that they targ...

Background: Stem cell therapy has been developed as an effective treatment method for the heart failure. Also, extracellular matrix has shown the positive effects in stem cell differentiation and myocardial tissue organization. Cardiogel is a native cardiac extracellular matrix (ECM) derived from cardiac fibroblasts. In the present study the role of cardiogel is examin...

heart failure is one of the leading causes of death worldwide. end stage disease often requires heart transplantation, which is hampered by donor organ shortage. tissue engineering represents a promising alternative approach for cardiac repair. for the generation of artificial heart muscle tissue several cell types, scaffold materials and bioreactor designs are under investigation. in this revi...

Background: Fibronectin type III domain-containing 5 proteins (Fndc5), an exercise hormone, formerly known as peroxisomal protein that was cloned in 2002. Transcript profile analysis of Fndc5 revealed high degree of expression in heart, skeletal muscle and brain. Our recent studies indicated a significant increase (approximately 10 folds) in mRNA level of Fndc5 when mouse embryonic stem cells w...

background: mesenchymal stem cells (mscs) are multipotential cells and their therapeutic potency is under intense investigation. studying the effect of different induction factors on mscs could increase our knowledge about the differentiation potency of these cells. one of the most important sources of these factors in mammalian body is platelet. platelet lysate (pl) contains many growth factor...

Introduction: Myocardial perfusion SPECTby 99mTc-Sestamibi and 99mTc-Tetrofosmin radiopharmaceuticals usually presents a false significant increase in the radiotracer uptake in the inferior myocardium due to the uptake in organs such as liver, bowel, stomach and biliary system. The present study evaluated a suitable Slit angle for differentiating extra-car...