Abstract Carnosine (β-Alanyl-L-Histidine) is a naturally occurring endogenous dipeptide and over-the-counter dietary supplement with multimodal mechanism of action. The use carnosine its analogues in as diverse mode action application. Carnosine’s ready availability protective properties make it an interesting candidate for clinical use. We have now examined the registered studies. In cross-sec...

Objective: Cancer has risen as the main cause of diseases with the highest rate of mortality in the world. Drugs used in cancer, usually demonstrate side effects on normal tissues. On the other hand, anticancer small peptides, effective on target tissues, should be safe on healthy organs, as being naturally originated compounds. In addition, they may have good pharmacokinetic properties. carnos...

Objective Cancer has risen as the main cause of diseases with the highest rate of mortality in the world. Drugs used in cancer, usually demonstrate side effects on normal tissues. On the other hand, anticancer small peptides, effective on target tissues, should be safe on healthy organs, as being naturally originated compounds. In addition, they may have good pharmacokinetic properties. carnosi...

The exercise performance of thoroughbred racing horses is affected by factors such as body weight, muscle type, and nutrition . Carnosine (β-alanyl histidine), a small and water-soluble dipeptide, in the muscle is a factor that contributes to the exercise performance of animals . This peptide and its analogues anserine (1-methyl-carnosine) are present in the skeletal muscles and nervous tissues...

In the historical city center of Ghent in Belgium, an international group of scientists gathered for a 3-day meeting dedicated to carnosine research. The meeting took place in July 2011, which is more than 10 years following the previous congress of this kind, organized by Alexander Boldyrev in Moscow in the year 2000. The Moscow meeting was held on the occasion of the centenary of Gulewitch an...

Background & Aims: The present study evaluated the effect of some synthesized linear and cyclic Carnosine analogues on cells human glioblastoma multiforme (GBM). purpose this research was to exposure Carnosin astrocytoma using several experiments. Methods: mass spectral measurements were performed a 6410 Agilent LCMS triple quadrupole spectrometer (LCMS) with an electrospray ionization (ESI) in...

Background and Objective: Diabetes mellitus (DM) affects synaptic plasticity in the hippocampus, leading to impairments in learning and memory. L-carnosine, an endogenous dipeptide, is reported to exhibit anti-diabetic and antioxidant effects. Therefore, this study was designed to evaluate its effect on learning and memory in diabetic rats. Materials and Methods: In the present study, male Wis...

Carnosine is a dipeptide compound that is found in many dietary supplements and food products. Carnosine has many functions in the body, such as alleviating oxidative stress on tissues by acting as an antioxidant compound. Carnosine, therefore, has important anti-aging properties. Carnosine is also capable of forming protective sequestration structures around heavy metal ions; this process of c...

The physiological function of L-carnosine (beta-alanyl-L-histidine) synthesized in mammalian muscles has been unclear. Previously, we observed that intravenous (i.v.) injection of L-carnosine suppressed renal sympathetic nerve activity (RSNA) in urethane-anesthetized rats, and L-carnosine administered via the diet inhibited the elevation of blood pressure (BP) in deoxycorticosterone acetate sal...