نتایج جستجو برای Chondrogenesis

تعداد نتایج: 1542  

Journal: :The Journal of Cell Biology 1973
Ronald R. Minor,

Light and electron microscopy are used in this study to compare chondrogenesis in cultured somites with vertebral chondrogenesis These studies have also characterized some of the effects of inducer tissues (notochord and spinal cord), and different nutrient media, on chondrogenesis in cultured somites Somites from stage 17 (54-60 h) chick embryos were cultured, with or without inducer tissues, ...

Journal: :Acta medica Okayama 2010
Takayuki Furumatsu, Toshifumi Ozaki,

Epigenetics is an essential mechanism to control gene expression and fundamental cellular processes. DNA methylation in CpG-rich promoters correlates with gene silencing. Histone modification including histone acetylation and deacetylation determines the stability of the chromatin structure. Condensed chromatin (heterochromatin), which has a higher-order histone-DNA structure, prevents the acce...

Journal: :The Journal of biological chemistry 2002
Masuhiro Tomita, Martina I Reinhold, Jeffery D Molkentin, Michael C Naski,

Nuclear factor of activated T-cells (NFAT) and calcineurin are essential regulators of immune cell and mesenchymal cell differentiation. Here we show that elevated intracellular calcium induces chondrogenesis through a calcineurin/NFAT signaling axis that activates bone morphogenetic protein (BMP) expression. The calcium ionophore, ionomycin, induced chondrogenesis through activation of calcine...

2010
J. P. Benthien, P. Behrens,

Options for the treatment of cartilage defects include chondral resurfacing with abrasion, debridement, autologous chondrocyte transplantation (ACT), matrix-induced chondrocyte transplantation (MACI), or osteochondral autologous transplantation (OATS). This article describes the new method of autologous matrix-induced chondrogenesis (AMIC), a 1-step procedure combining subchondral microfracture...

2003
Cheng-Ming Chuong,

This paper reviews the molecular and cellular events during precartilage condensation and describes the application of a new retroviral gene transduction procedure. In micromass cultures, dissociated mesenchymal cells interact to form cartilage nodules. Cells first form small aggregates, then bigger clusters. Next, through rearrangement, they consolidate to form precartilage condensations which...

2003

Light and electron microscopy are used in this study to compare chondrogenesis in cultured somites with vertebral chondrogenesis These studies have also characterized some of the effects of inducer tissues (notochord and spinal cord), and different nutrient media, on chondrogenesis in cultured somites Somites from stage 17 (54-60 h) chick embryos were cultured, with or without inducer tissues, ...

2013
Jin Shang, Huan Liu, Yue Zhou,

Cartilage has limited repair and regeneration capacity, thus damage of cartilage often results in its dysfunction and even chronic diseases like osteoarthritis (OA). Chondrogenesis induced by tissue-engineering methods is essential to treating cartilage-related diseases. MicroRNAs (miRNAs) are a class of small non-coding single-stranded RNAs which exert their biological effects by binding to th...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
Donald J Responte, Jennifer K Lee, Jerry C Hu, Kyriacos A Athanasiou,

Biomechanics plays a pivotal role in articular cartilage development, pathophysiology, and regeneration. During embryogenesis and cartilage maturation, mechanical stimuli promote chondrogenesis and limb formation. Mechanical loading, which has been characterized using computer modeling and in vivo studies, is crucial for maintaining the phenotype of cartilage. However, excessive or insufficient...

Journal: :The Journal of Biophysical and Biochemical Cytology 1960
Gabriel C. Godman, Keith R. Porter,

The role of the cells in the fabrication of a connective tissue matrix, and the structural modifications which accompany cytodifferentiation have been investigated in developing epiphyseal cartilage of fetal rat by means of electron microscopy. Differentiation of the prechondral mesenchymal cells to chondroblasts is marked by the acquisition of an extensive endoplasmic reticulum, enlargement an...

Journal: :European cells & materials 2006
F M Altaf, T M Hering, N H Kazmi, J U Yoo, B Johnstone,

The ATDC5 cell line exhibits the multistep chondrogenic differentiation observed during endochondral bone formation. However, it takes up to two months to complete the process of cell expansion, insulin addition to promote differentiation and further changes in culture conditions effectively to induce hypertrophy. We sought to produce consistent chondrogenesis with significant hypertrophic diff...

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