Cancer has emerged as a leading cause of death throughout the world. Peptides are a novel class of anticancer agents that can specifically target cancer cells with low toxicity to normal tissues and thus, offer new opportunities for future cancer treatment. On the other hand, Ciprofloxacin, an antibiotic, also known to its anticancer property for enabling cell cycle arrest and creating double s...

Cancer has emerged as a leading cause of death throughout the world. Peptides are a novel class of anticancer agents that can specifically target cancer cells with low toxicity to normal tissues and thus, offer new opportunities for future cancer treatment. On the other hand, Ciprofloxacin, an antibiotic, also known to its anticancer property for enabling cell cycle arrest and creating double s...

18.1 The Challenge of Delivery of Oligonucleotide Analogs and siRNA into Cells in Culture and In Vivo ............................................ 313 18.2 Chemical Synthesis of Peptide–Oligonucleotide Conjugates .............. 314 18.2.1 Synthesis of CPP Conjugates to Phosphate-Containing Oligonucleotides ...................................................................... 315 18.2.2 Synthes...

The field of peptide derivatization by metal-catalyzed C−H activation has been mostly directed to modify the side chains, but poor attention given backbone. Here we report a ruthenium-catalyzed activation/annulation process that can chemoselectively backbone producing functionalized isoquinolone scaffolds with high regioselectivity in rapid and step-economical manner. This strategy is character...

A modular approach has been developed for enzymatic ligation of peptides/proteins with oligonucleotides through the design tag phosphoramidites as adaptors, paving way towards streamlined production peptide/protein-oligonucleotide conjugates.

Recently cationic porphyrin-peptide conjugates were synthesized to enhance the cellular uptake of porphyrins or deliver the peptide moiety to the close vicinity of nucleic acids. DNA binding of such compounds was not systematically studied yet. We synthesized two new porphyrin-tetrapeptide conjugates which can be considered as a typical monomer unit corresponding to the branches of porphyrin-po...