background there are hoarding documents for the biological importance of cyclooxygenase-2 (cox-2) in pancreatic carcinogenesis. we aimed to thoroughly investigate the dna sequence variations of whole cox-2 exons in a large case-control study of pancreatic cancer by direct sequencing.   methods the entire exonic regions of cox-2 including 10 exons were sequenced in the germline dna of 96 patient...

non-steroidal anti-inflammatory drugs (nsaids) are the competitive inhibitors of cyclooxygenase (cox), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (pgs). their use is associated with the side effects such as gastrointestinal and renal toxicity. the therapeutic anti-inflammatory action of nsaids is produced by the inhibition of cox-2, while the ...

In the field of molecular modeling, docking may be a method which predicts well-liked orientation any molecule to receptor make stable complex. Knowledge successively could also able predict strength association or binding affinity between two molecules using, for instance, scoring functions. Cyclooxygenase-2 (COX-2) inhibitors block cyclooxygenase-2 (COX-2), an enzyme that promotes inflammatio...

several studies point to an important function of cyclooxygenase (cox) and prostaglandin signaling in models of synaptic plasticity which is associated with n-methyl-d-aspartate receptors (nmdars). cyclooxygenase gene is suggested to be an immediate early gene that is tightly regulated in neurons by nmda dependent synaptic activity. nonsteroid antiinflammatory drugs (nsaids) exert their antiinf...

Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...

Ibuprofen and aspirin are frequently used to relieve inflammation, pain, fever. These the two most significant non-steroidal anti-inflammatory drugs (NSAIDs). They prevent development of prostaglandin by blockampounds have been assessed ibuprofen as well quantum mechanical computations. Density functional theory (DFT) with B3LYP/6-31G+ basis function has elucidate thermo-chemical, molecular orb...

Inhibition of cyclooxygenase-2 (COX-2) has been extensively studied as an approach to reduce proinflammatory markers in acute brain diseases, but the anti-neuroinflammatory role cyclooxygenase-1 (COX-1) inhibition rather neglected. We report that m-terphenylamine derivatives are selective COX-1 inhibitors, able block microglia inflammatory response and elicit a neuroprotective effect. These com...

The endometrium undergoes a dynamic proliferation of cells and vascular tissue under the influence ovarian steroid hormones. Implantation is an essential process in development pregnancy, where there close contact between embryo uterus, including supposition, adhesion, invasion. changes occur human endometrium, endometrial secretion changes, blood vessels, immune response, leading to uterine re...

In this study, we focused on screening and simulating the interaction between anti-inflammatory proteins 50 compounds isolated from Millettia dielsiana Harms ex Diels. 39 out of that violated no Lipinski’s rule five were sorted as favorable for drug development selected studies further. Then, a molecular docking study into binding sites COX-1 COX-2 allowed shedding light mode these potential CO...