objective: envenomation by heamotoxic snakes constituted a critical health occurrence in the world. bleeding is the most sever consequence following snake bite with viperid and crothalid snakes. it is believed that the degradation of vascular membrane caused hemorrhage; in contrast, some suggested that direct cytotoxicity has role in endothelial cell disturbances. this study was to evaluate the...

the aim of our work was to compare cytotoxic and membrane-damaging effects of o. majorana l. essential oil and linalool on hep g2 and to investigate their possible protective (antioxidant) effects against h2o2 induced membrane damage. the oils were investigated by gc and gc-ms and antioxidant activity was evaluated by dpph and -carotene–linoleic acid assays. assessment of cell viability was ma...

background: in this study, the effects of three structural analogues of adenosine upon proliferation of human tumor cells were investigated. previous research showed a cytotoxic effect of adenosine via a3 receptor and a1 receptor and sometimes this effect was receptor independent. the researches showed a differential cytotoxic effect of adenosine and its a3 agonists on cancerous cells, while ot...

this study discusses the effect of complexes of chitosan grafted polyethylenimine(ch-pei) with plasmid dna on viability of mesenchymal stem cells(mscs) derived from human marrow. ch-pei/pdna nanoparticles were synthesized through the complex coacervation method using pires plasmid containing green fluorescent protein (gfp) gene. to confirm the complexation, samples were run through an agarose g...

conclusions the outcome of this study is that the oca has no toxic effect on h9c2 cells. results the results showed that the percentage of survived cells amount of extract dilution ratio (1:4; 1:2; 1) were 80.4%; 79.6%, 77.5% respectively. analysis of statistical test results does not show any significant differences between the optical density of the extract dilutions, and the control group in...

background: a strong antimicrobial synergism between chlorhexidine (chx) and hydrogen peroxide (h2o2) has been reported, but there is not enough data on the cytotoxicity of this combination. the primary aim of this study was to evaluate the cytotoxicity of chx-h2o2 combination in different concentrations and secondary aim is to assess the infl uence of h2o2 on cytotoxicity of chx on cultured hu...

introduction: root canal disinfection is an important step in regenerative endodontic treatments. an ideal irrigating solution must have high antimicrobial activity and minimum cytotoxicity. this study sought to assess the effect of some irrigating solutions on stem cells from the human apical papilla (scap) after different periods of exposure. methods and materials: stem cells were isolated fr...

In order to clarify that squalene monohydroperoxide (SQOOH) correlates with changes in morphology through cytotoxicity and establish in vitro evaluation of the cytotoxicity of lipid hydroperoxide, the effect of SQOOH on cytotoxicity and morphology in normal human epidermal keratinocytes (NHEK(B)) and the Gunze three-dimensional cultured human skin model (Vitrolife-skin) was investigated. Additi...