background: multiple sclerosis (ms) is a disease of the immune system that creates damage of learning and memory in that. using probiotic supplements is recommended for preventing ms disease and improving memory. this study aimed to investigate the effect of lactobacillus plantarum (lp) and bifidobacterium b94 (bb94), on acquisition phase of spatial memory in the local demyelination of rats` hi...

introduction: spinal cord injuries are accompanied with significant demyelination of axons and subsequent locomotor dysfunction. to identify the extent of damage following electrolytic lesion of ventrolateral white matter, essential area for initiation of locomotor activity, we assessed demyelination as well as alteration in motor performance. moreover, the protective effect of estradiol as a c...

abstract acute disseminated encephalomyelitis (adem) is a rare immune mediated and demyelinating disease of the central nervous system that usually affects children. it as a monophasic disorder related with multifocal neurologic symptoms. here in this paper we report seven cases of adem in pediatrics and besides a review of literatures are presented.

Background: Cervical spinal cord is important and radiosensitive. It is the most critical organ for the head and neck (H&N;) cancer patients during radiotherapy. If the delivered dose to the cord is more than tolerance dose, demyelination may occur. Objective: Current study aims to analyze the post radiotherapy status of cord in the H&N; cancer patients.Material and Methods: In this a...

Introduction: Nogo-A and Nogo receptor (NgR) are expressed in the subventricular zone (SVZ) stem cells. NgR plays critical inhibitory roles in axonal regeneration and remyelination. However, the role of NgR in SVZ niche behaviors in demyelination context is still uncertain. Here we investigated the effects of NgR inhibition on SVZ niche reaction in a local model of demyelination in adult mouse ...

Distinction between acute disseminated encephalomyelitis and acute multiple sclerosis is often clinically difficult. Perivenous demyelination is the pathological hallmark of acute disseminated encephalomyelitis, whereas confluent demyelination is the hallmark of acute multiple sclerosis. We investigated whether perivenous demyelination versus confluent demyelination distinguishes acute dissemin...

OBJECTIVE The aim of this study was to investigate whether the extent and topography of cerebral demyelination correlates with and predicts disease progression in patients with juvenile metachromatic leukodystrophy (MLD). METHODS A total of 137 MRIs of 46 patients with juvenile MLD were analyzed. Demyelination load and brain volume were quantified using the previously developed Software "clus...

MOG antibody disorder presenting as a combined central and peripheral demyelination (CCPD) is uncommon. CCPD has been associated with other primary syndromes such multiple sclerosis, neuromyelitis optica or chronic inflammatory demyelinating polyneuropathy. Here, the authors describe diagnosis management of 21-year-old female historically sequential plaques in her right thalamus, cervical cord,...

background: multiple sclerosis (ms) is a disease of the immune system that creates damage of learning and memory in that. using probiotic supplements is recommended for preventing ms disease and improving memory. this study aimed to investigate the effect of lactobacillus plantarum (lp) and bifidobacterium b94 (bb94), on acquisition phase of spatial memory in the local demyelination of rats` hi...

Introduction: Demyelination is one of the main causes of neurological disability. It is the end product of numerous pathological processes, multiple sclerosis (MS) being the most common cause. More than 70% of the MS patients suffer from optic disturbances. This disease commonly affects the optic pathway, particularly the optic nerves and chiasm. Several attempts have been made to produce a ...