quantum chemical calculations, based on density functional theory (dft) method, were performed on calix[4]arene and polychlorinated dibenzo-p-dioxins (pcdds) in gas and liquid phases for comparison purposes. the simulation results show the 1,2,3,4, 6,7,8,9-octachlorodibenzo-p-dioxin (ocdd) is quite a reactive dioxin. this paper attempts to examine the possibility of dioxin adsorption by calix[n...

This research aimed to determine the effect of α-tocopherol on count spermatogenic and Leydig cells in rats (Rattus norvegicus) exposed 2,3,7,8 tetrachlorodibenzo-p-dioxin (dioxin). Dioxin is an endocrine-disrupting agent that adversely affects reproductive health, while maintains fertility. used 25 aged 10-12 weeks weighing 150-200 grams. Rats were divided into five groups (K, P0, P1, P2 P3). ...

dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes. however, there were inconsistent results in epidemiology studies. in view of this difference, we conducted a systematic review and meta-analysis to examine this association and to assess the heterogeneity among studies. comprehensive literature searches w...

Quantum chemical calculations, based on Density Functional Theory (DFT) method, were performed on Calix[4]arene and Polychlorinated Dibenzo-p-dioxins (PCDDs) in gas and liquid phases for comparison purposes. The simulation results show the 1,2,3,4, 6,7,8,9-octachlorodibenzo-p-dioxin (OCDD) is quite a reactive dioxin. This paper attempts to examine the possibility of dioxin adsorption by Calix[n...

The elution order of 209 polychlorinated biphenyls (PCBs) was determined using five types commercially available capillary columns (VF-Xms, Rtx-20, VF-35ms, VF-1301ms and VF-200ms). In addition, the interference among molecular ion peaks PCDDs non-dioxin like PCB congeners, which affect during dioxin analysis by GC/MS, clarified.

In Japan, the largest source of dioxin is solid waste incineration plants. Because workers employed at these plants handle fly ash and slag contaminated by dioxins, they can take dioxins into the body during work and their health may be adversely effected. This paper describes the dioxin exposure concentration, daily dioxin intake and blood dioxin level in workers employed at municipal incinera...

In October 2010, nine ministries and commissions of China jointly issued Guidance on the Strengthening of Dioxin Pollution Prevention [Ministry of Environmental Protection of People's Republic of China (MEP) 2010], which requires key dioxin-emitting industries to carry out comprehensive actions to reduce dioxin emissions. This is a major historical milestone in China's fight against dioxin poll...

The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins--widespread and persistent pollutants whose toxic effects include tumor promotion, teratogenesis, wasting syndrome and chloracne. Elimination of Ahr in mice eliminates dioxin toxicity but also produces adverse effects, some seemingly unrelated to dioxin. Thus the relationship between the toxic and diox...

The molecular chaperone complex hsp90-p23 interacts with the dioxin receptor, a ligand-dependent basic helix-loop-helix (bHLH)/Per-Arnt-Sim domain transcription factor. Whereas biochemical and genetic evidence indicates that hsp90 is important for maintenance of a high-affinity ligand binding conformation of the dioxin receptor, the role of hsp90-associated proteins in regulation of the dioxin ...

The pollutant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (“dioxin”), has been implicated in the etiology of a wide variety of human birth defects. In an effort to identify pharmacological blockers of dioxin-induced terata, we performed a histological and microscopic analysis of the developing murine palate that had been exposed to dioxin. In both in vivo and in vitro model systems, we observed that d...