abstractin the last step of desolvation method for preparation of albumin nanoparticles, glutaraldehyde (ga) is added to stabilize the newly formed nanoparticles. due to undesirable effects of ga, the objective of this study was to evaluate alternative methods of crosslinking including ultraviolet (uv) irradiation, adding of glucose and combination of both methods. the nanoparticles were prepar...

Background: Gamete cryopreservation is an inseparable part of assisted reproductive technology, and vitrification is an effective approach to the cryopreservation of oocytes. The aim of this study was to investigate vitrification effects on the expression levels of mitochondrial transcription factor A (Tfam) and mitochondrial-encoded cytochrome c oxidase subunit 1 (Cox1) in mouse metaphase II o...

Docetaxel is widely used in the treatment of metastatic breast cancer. However, its effectiveness is limited due to chemoresistance and its undesirable side effects. The combination of chemotherapeutic agents and natural compounds is an effective strategy to overcome drug resistance and the ensuing inevitable toxicities. Quercetin is a natural flavonoid with strong antioxidant and anticancer ac...

background: metastatic prostate cancer is one of the most important cancers among men worldwide. androgen ablation therapy can be used in treatment of these patients; however, most will progress to metastatic hormone-refractory prostate cancer. in this regard, docetaxel has been approved to treat metastatic hormone-refractory prostate cancer in the united states. in this study, we aimed to inve...

Docetaxel, a chemotherapeutic agent currently used for improving survival of prostate cancer patients, suffers from low therapeutic index. The objective of this study was to prepare a new docetaxel derivative conjugated to deslorelin, a luteinizing hormone-releasing hormone (LHRH) superagonist, and to determine whether it enhances docetaxel potency in vitro and in vivo. Because docetaxel is not...

Background: Pharmacokinetics of docetaxel can be measured in vivo using positron emission tomography (PET) and [C]docetaxel. The objective of this study was to investigate whether a tracer [ Methods: Docetaxel-naïve lung cancer patients underwent two [ C]docetaxel PET study could predict tumor uptake of unlabeled (cold) docetaxel during a therapeutic infusion. C]docetaxel PET scans; one after b...

BACKGROUND We previously found 70 mg flat-dose docetaxel coadministered with ketoconazole to modulate CYP3A4 to be the maximum tolerated dose that resulted in comparable docetaxel area under the plasma concentration-time curve (AUC) as 75-100 mg/m² docetaxel. PATIENTS AND METHODS We compared cycle 1 docetaxel pharmacokinetics and pharmacodynamics between ketoconazole-modulated (70 mg flat-dos...

background: emergence of drug resistance has brought major problems in chemotherapy. using nutrients in combination with chemotherapy could be beneficial for improvement of sensitivity of tumors to drug resistance. soybean-derived isoflavones have been suggested as chemopreventive agents for certain types of cancer, particularly breast cancer. in this study, the synergistic effects of soy isofl...

Purpose: Tumor resistance to docetaxel may be associated with reduced drug concentrations in tumor tissue. Positron emission tomography (PET) allows for quantification of radiolabeled docetaxel ([C]docetaxel) kinetics and might be useful for predicting response to therapy. The primary objective was to evaluate the feasibility of quantitative [C]docetaxel PET scans in lung cancer patients. The s...