abstract background: diabetic neuropathy is the most common micro-vascular complications of diabetes. the drugs including gabapentin and duloxetine are often used for the treatment of pain associated with diabetic neuropathy. this study aimed to compare the efficacy of duloxetine and gabapentin in the treatment of diabetic peripheral neuropathy. materials and methods: totally, 34 patients aged ...

Duloxetine is a potent and balanced dual inhibitor of serotonin and norepinephrine reuptake being investigated for the treatment of depression and urinary incontinence. The disposition of duloxetine was studied in four healthy human subjects after a single 20.2-mg (100.6 microCi) oral dose of [14C]duloxetine in an enteric-coated tablet. The mean total recovery of radioactivity (+/- S.E.M.) afte...

conclusions this preliminary assessment suggests that duloxetine may be a medication of interest in the treatment of children with adhd. further controlled studies with larger samples are required to evaluate the efficacy of duloxetine in treatment of children with adhd. results ten children with a mean age of 8.40 ± 1.67 years terminated the trial. a significant reduction in cprs-r and its sub...

Background: The neuroprotective effects of duloxetine, as an antidepressant agent, and the neurodegenerative effects of methamphetamine have been shown in previous studies. Nonetheless, their exact neurochemical and behavioral effects are still unclear. In the current study, we sought to clarify the molecular mechanisms involved in the protective effects of duloxetine against methamphetamine-in...

History of introduction duloxetine in medical practice, mechanism action and using concervative treatment women men with stress urinary incontinence are shown. Modern structure external urethral sphincter was shown increasing tone under influence.
 Duloxetine recommended by International Continent Society for initial but this drug gives only improvement urine continence quality life side e...

background: treating inflammatory bowel disease (ibd) with antidepressants might be of utility to improve patient’s condition. the aim of this study was to assess the efficacy of duloxetine on depression, anxiety, severity of symptoms, and quality of life (qol) in ibd patients. materials and methods: in a randomized, double-blind, controlled clinical trial on  2013-2014, in alzahra hospital (is...

This was a 12-week, randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of duloxetine, a selective serotonin and norepinephrine reuptake inhibitor, in 354 female patients with primary fibromyalgia, with or without current major depressive disorder. Patients (90% Caucasian; mean age, 49.6 years; 26% with current major depressive disorder) received duloxetine 60 m...

Fibromyalgia syndrome (FMS) is a widespread pain condition associated with a wide range of additional symptoms including fatigue, insomnia, depression, anxiety and stiffness. Duloxetine is one of three medications currently FDA approved for use in FMS management. Duloxetine is a mixed serotonin and norepinephrine reuptake inhibitor (SNRI) that functions by increasing central nervous system leve...

Duloxetine is a balanced serotonin-norepinephrine reuptake inhibitor. Duloxetine-induced liver injury in patients with preexisting liver disease or chronic alcohol use is known. However, we have found that duloxetine can also induce liver injury in cases without those risk factors. We recommend that clinicians should monitor liver function carefully following duloxetine treatment.