to understand the mechanism of multiple sclerosis (ms), an autoimmune demyelinating disease, the researchers developed an experimental animal model for ms, which is called eae (experimental allergic encephalomyelitis). there are several methods for inducing this animal model. in this research the active eae, which is developed by injecting bovine myelin antigens into genetically susceptible ani...

To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptibl...

multiple sclerosis (ms) is a neurodegenerative and autoimmune disease that it’s molecular etiology and factors involving in its progression remains unknown. in this study for evaluation effect of mercuric on progression of ms we investigated the additive effect of mercuric sulfide on the brain mitochondrial dysfunction in experimental autoimmune encephalomyelitis (eae) model of ms in c57bl/6 mi...

experimental allergic encephalomyelitis (eae), a demyelinating disease induced in the animals parallels multiple sclerosis in human in several aspects, provides a useful model to investigate multiple sclerosis. in this study, we have therefore used this model to study functions of nerve growth factor (ngf) in eae. ngf with considerable effects on neuron survival, proliferation and differentiati...

Experimental autoimmune encephalomyelitis (EAE) is the most relevant animal model to study demyelinating diseases such as multiple sclerosis. EAE can be induced by active (active EAE) or passive (at-EAE) transfer of activated T cells in several species and strains of rodents. However, histological features of at-EAE model in C57BL/6 are poorly described. The aim of this study was to characteriz...

Background and objectives: Scrophularia megalantha is a native Iranian plant. In folk remedies, the species of the genus are used to treat stomach ulcers, goiter, eczema, cancer, psoriasis, and gall; however, there is not much research about S. megalantha. The current study aimed at evaluating the therapeutic effect of Scrophularia megalantha, a medic...

multiple sclerosis (ms) is a progressive and autoimmune neurodegenerative disease of the central nervous system (cns). this disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. experimental allergic encephalomyelitis (eae) is a widely accepted animal model for ms. eae is created in animals by injecting the tissue of myelin basic pr...

In their Point of View entitled "Experimental Allergic Encephalomyelitis: A Misleading Model of Multiple Sclerosis," Sriram and Steiner(1) wrote, "The most disappointing aspect of EAE [experimental allergic encephalomyelitis] as a potential model for MS is its almost total inability to point toward a meaningful therapy or therapeutic approach for MS." Actually, EAE has led directly to the devel...