Background Poor and fragmentary data was available regarding the effects of recombinant-LH (r-LH) in in-vitro granulosa and theca cells of human origin. No data was available from in vivo studies regarding the effects of r-LH supplementation on SCF,EGF,ERK-1/2 and AKT-1 pathways in the follicular fluid of older-poor-responder women undergoing IVF cycle. Evidence from in-vitro and animal studies...

objective(s): oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. licochalcone b, an extract of licorice root, has shown antioxidative properties. this study was to investigate the effects and mechanisms of licochalcone b in ethanol-induced hepatic injury in an in vitro study. materials and methods: an in vitro model of ethanol-induced cytotoxicity in brl cel...

In this study, the effect of topiramate, as an antiepileptic drug, was evaluated on morphine craving in rats. The conditioned place preference (CPP) test was used for this purpose. Repeated administration of morphine (10 mg/kg, i.p. for 4 days) induced significant CPP. Administration of topiramate (50 and 100 mg/kg, i.p. for 4 days) with each morphine administration decreased the acquisition of...

Objective(s): Oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. Licochalcone B, an extract of licorice root, has shown antioxidative properties. This study was to investigate the effects and mechanisms of licochalcone B in ethanol-induced hepatic injury in an in vitro study. Materials and Methods: An in vitro model of Ethanol-induced cytotoxicity in BRL cel...

In this study, the effect of topiramate, as an antiepileptic drug, was evaluated on morphine craving in rats. The conditioned place preference (CPP) test was used for this purpose. Repeated administration of morphine (10 mg/kg, i.p. for 4 days) induced significant CPP. Administration of topiramate (50 and 100 mg/kg, i.p. for 4 days) with each morphine administration decreased the acquisition of...

Background The hypothesis that the LDA (low-dose-aspirin) could improve ovarian and uterine perfusion induced clinicians to administer it in women undergoing IVF. Unfortunately, no studies have shown significant differences in terms of pregnancy rate among patients treated or untreated with LDA. The absence of proven clinical benefits of LDA supplementation, led us to wonder whether aspirin, ad...

background: in the field of cellular therapy, the impact of confluence degree on harvesting or differentiation of bmmscs and the effect of cell-to-cell contact remain controversial. therefore, the effect of confluence on properties of bmmscs was studied and efficiency of confluence-associated osteogenic differentiation was identified. materials and methods: the impact of 20, 50, 70, 80 and 100%...

objective: signaling pathways such as extracellular regulated kinase/mitogen activated protein kinase (erk/mapk) have increased activity in leukemia. ribosomal 6 kinase (rsk4) is a factor downstream of the mapk/erk pathway and an important tumor suppressor which inhibits erk trafficking. decrease in rsk4 expression has been reported in some malignancies, which leads to an increase in growth and...

background: in the field of cellular therapy, the impact of confluence degree to harvest or differentiate bmmscs and the effect of cell-to-cell contact remains controversial. therefore, the effect of confluence on bmmscs properties was studied and confluence-associated osteogenic differentiation efficiency was identified. materials and methods: the impact of confluences at 20, 50, 70, 80 and 10...