The aim of the present study was to evaluate, by means of a temporal pattern analysis, rat’s behavior in the elevated plus maze test. A specific software called THEME has been used. On the basis of an ethogram encompassing 24 behavioral elements, results demonstrated that 14 components represented the 98% of the displayed activities. 145 different temporal patterns have been detected; length di...

Introduction: Previous studies have shown that cannabinoidergic system is involved in anxiety. However, there are controversial reports in the experimental studies. The aim of this study is to evaluate the effect of pharmacological stimulation or blocking of CB1 receptors and inhibition of endocannabinoid degradation in anxiety like behavior in elevated plus-maze (EPM) test in rat. The EPM is o...

α-Galycoceramide (α-Galcer) or the common name of krn7000 is an α-gelasphin derivative. The α-Galcer structure consists of a galactose combined with a ceramide in an α-configuration. Social isolation (SI) has been linked with enhanced inflammation, through modifications in transcriptional pathways linked with glucocorticoid, to stress. Our hypothesis is to investigate mediatory role of glucocor...

The present study evaluated the correlation between the behavior of mice in the forced swimming test (FST) and in the elevated plus-maze (PM). The effect of the order of the experiments, i.e., the influence of the first test (FST or PM) on mouse behavior in the second test (PM or FST, respectively) was compared to handled animals (HAND). The execution of FST one week before the plus-maze (FST-P...