the molecular mechanisms of the fact that more than 50% of the individuals with the same genetic make up (e.g. identical twins in schizophrenia) do not show the same psychiatric phenotype remained undefined in psychiatry. this along with the failure to find responsible genes with major effects in psychiatric disorders and lack of consistency of genetic association studies led to the current una...

objective:glioblastoma is an invasive tumor of the central nervous system. epigenetic therapy of cancer is potentially very useful in reversing some of cancer defects due to reversibility of epigenetic alterations. meg3 is a tumor suppressor long non-coding rna (lncrna) that expresses in the majority of normal tissues. methylation of the meg3 promoter region elicits a decrease in its expression...

thyroid cancer, the most common endocrine malignancy worldwide, originates from follicular epithelial cells. it is classified as a well-differentiated thyroid carcinoma (wdtc), which includes both follicular (ftc) and papillary types (ptc), poorly differentiated thyroid carcinomas (pdtc), anaplastic thyroid carcinoma (atc), and/or arising from para-follicular calcitonin producing cells involve m...

dna methylation as epigenetic mark plays a key role in normal differential and developmental processes as well as in dynamic gene regulation at the genomic level. to assess dna methylation pattern in different developmental stages of aeluropus littoralis, methylation sensitive amplified polymorphism (msap) was used. methylation and demethylation status at the ccgg recognition site were tracked ...

management of mesenchymal stem cells (mscs) capabilities to differentiate into osteogenic and chondrogenic lineages would be of utmost importance for their future use in difficult to treat cases of destroyed bone and cartilage. thus, an understanding of the epigenetic mechanisms as important modulators of stem cell differentiation might be useful. epigenetic mechanism refers to a process that r...

the most important risk factors for anxiety disorders include genes, early life stress, and current stress. these factors do not act independently but interact with each other throughout human development through examples such as epigenetic modifications and complex forms of learning. the neural substrate of pathological anxiety includes hyperactivity in the amygdala and other limbic brain regi...

Background Despite successful cloning of many mammalian species, the cloning efficiency is extremely low compared to that of IVF raising the possibility of the existence of epigenetic barrier preventing successful cloning. MaterialsAndMethods Using comparative transcriptome analysis comparing transcriptomes of IVF and SCNT embryos and that of donor cells, we identified epigenetic barrier and fi...