background: statins, widely used cholesterol-lowering agents, have also been demonstrated to have anti-inflammatory and immunomdulatory effects. objective: to evaluate the effects of atorvastatin in combination with interferon-β in the treatment of multiple sclerosis (ms) in a randomized controlled clinical trial. methods: multiple sclerosis patients were randomized independently, in a double b...

background: multiple sclerosis (ms) is the most common disabling neurological disease. hand dysfunction is one of the main complaints of patients with ms. the present study aimed to compare hand dexterity of ms patients with low expanded disability status scale (edss) scores and healthy adults. it also sought to identify the predictors of disability status of patients with ms based on their man...

  Background: Multiple Sclerosis (MS) is the most common disabling neurological disease. Hand dysfunction is one of the main complaints of patients with MS. The present study aimed to compare hand dexterity of MS patients with low Expanded Disability Status Scale (EDSS) scores and healthy adults. It also sought to identify the predictors of disability status of patients with MS based on their m...

Objectives: Multiple Sclerosis (MS) is a chronic and disabling disease of the nervous system. This study was conducted to determine the effect of isometric exercises on balance and ability in the patients with MS.  Methods: Sixty MS patients participated in this randomized controlled trial study and patients were randomly assigned into treatment and control groups. Treatment group partici...

ramadan fasting predispose multiple sclerosis (ms) patients to a great challenge. clinicians should have practical knowledge about the effects of fasting on ms. a mini-symposium was held in 2013 to answer the common questions about fasting in ms patients. in current review we present a summary of the mentioned mini-symposium.generally, fasting is possible for most stable ms patients. thorough m...

BACKGROUND Multiple Sclerosis (MS) is the most common disabling neurological disease. Hand dysfunction is one of the main complaints of patients with MS. The present study aimed to compare hand dexterity of MS patients with low Expanded Disability Status Scale (EDSS) scores and healthy adults. It also sought to identify the predictors of disability status of patients with MS based on their manu...

It is commonly recognized that proinflammatory cytokines in patients with multiple sclerosis (MS) may increasingly cause inflammation. In this regard, the current study was aimed to shed light on the effectiveness of eight-week Pilates training program at interleukin-18 (IL-18) stage, severity of fatigue and balance as well as physical disability in females with MS. This study was a quasi-exper...

Abstract Background About 40–70% of patients with multiple sclerosis (MS) develop cognitive impairment (CI) throughout their life. We aim to study the influence MS on changes. This is a case–control fifty who met revised 2017 Mc Donald Criteria and age- sex-matched healthy subjects. The Expanded Disability Status Scale (EDSS) was used assess degree disability, Montreal Cognitive Assessment (MoC...

BACKGROUND The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Stat...

OBJECTIVE To better characterize the relationship between cerebral white matter lesion load (CWM-LL) and clinical disability by (1) covering the entire range of the Kurtzke Expanded Disability Status Scale (EDSS), (2) minimizing nonbiological sources of variability, and (3) increasing pathologic specificity by studying CWM lesions that are hypointense on T1-weighted magnetic resonance imaging. ...