Background: Recently, cartilage tissue engineering is the best candidate for regeneration of cartilage defects. We evaluated the potential of fibrin and PLGA/fibrin scaffolds in providing a suitable environment for growth and chondrogenic differentiation of human adipose derived stem cells (hADSCs) in the presence of icariin. Method: The Three-dimensional...

fibrin glue is used for control of bleeding in various surgical procedures. in this work the ability of fibrin glue to seal punctures in the vascular system is demonstrated. blood samples were taken from rabbits, fibrinogen was separated and fibrin glue was eventually prepared. the rabbits were anesthetized and a midline incision was carried out. the heart and abdominal aorta were exposed. punc...

Suitable alternatives are made for damaged or diseased organs and tissues in tissue engineering by combining cellular and molecular biology with materials and mechanical engineering. Fibrin is a critical blood component responsible for homeostasis, used extensively as a biopolymer scaffold in tissue engineering. This study summarizes the latest developments in organ and tissue regeneration usin...

Background: Tissue engineering has been investigated as a potential method for healing traumatized tissues. Biomaterials are material devices or implants used to repair or replace native body tissues and organs. The present study was conducted to evaluate the effects of decontamination methods on biological/mechanical properties and degradation/adhesion test of the platelet‑-rich fibrin (PRF) m...

spinal cord injury (sci) results in the damage of motor and sensory pathways. the molecular and cellular structure of the injury milieu has been shown to be vital for endogenous regeneration in most tissues. regeneration of injured central nervous system (cns) is limited by damaged cell environment. biomaterial scaffolds can reconstruct injured cns tissue following sci by promoting the migratio...

objective: ovarian and follicle transplantation may preserve fertility in young cancer survivors. in this study, we have transplanted preantral follicles using fibrin gel as a carrier and fibrin gel supplemented with platelet lysate (pl) as a rich source of angiogenic and growth factors. the purpose of this study was to evaluate the role of fibrin gel and pl in follicle transplantation. materia...

Fibrin glue is used for control of bleeding in various surgical procedures. In this work the ability of fibrin glue to seal punctures in the vascular system is demonstrated. Blood samples were taken from rabbits, fibrinogen was separated and fibrin glue was eventually prepared. The rabbits were anesthetized and a midline incision was carried out. The heart and abdominal aorta were exposed. ...

reconstruction methods are an essential prerequisite for functional rehabilitation of the stomatognathic system. plasma rich in growth factors (prgf) offers a new and potentially useful adjunct to bone substitute materials in bone reconstructive surgery. this study was carried out to investigate the influence of prgf and fibrin membrane on regeneration of bony defects with and without deprotein...

background: endometriosis is the presence of endometrial tissue outside of the uterine cavity and is the most common gynecologic disorder in women of reproductive age. we have preliminary evidence that in the presence of a 3-dimensional (3-d) fibrin matrix, human endometrial glands, stroma, and neovascularization can develop in vitro, mimicking the earliest stages of endometriosis. the aim of t...

background: connective tissue attachment following periodontal regenerative surgery is directly related to the attachment of fibrin clot on to the root surface during early wound healing events. the adhesion of fibrin clot to the root surface affected by periodontal disease depends on the biologic acceptance of the root surface which can be accomplished by various root conditioning procedures d...