in this paper, the quantitative structure activity-relationship (qsar) of the ccr2b receptor inhibitors was scrutinized. firstly, the molecular descriptors were calculated using the dragon package. then, the stepwise multiple linear regressions (sw-mlr) and the genetic algorithm multiple linear regressions (ga-mlr) variable selection methods were subsequently employed to select and implement th...

a robust and reliable quantitative structure-property relationship (qspr) study was established to forecast the melting points (mps)  of a diverse and long set including 250 drug-like compounds. based on the calculated descriptors by dragon software package, to detect homogeneities and to split the whole dataset into training and test sets, a principal component analysis (pca) approach was used...

Quantitative structure-retention relationships (QSRRs) are used to correlate paper chromatographic retention factors of disperse dyes with theoretical molecular descriptors. A data set of 23 compounds with known RF values was used. The genetic algorithm-multiple linear regression analysis (GA-MLR) with three selected theoretical descriptors was obtained. The stability and predictability of the ...

the metal sheets play an important role in the mechanical design, particularly in the aerospace structures. the rivet connections are frequently used to connect these sheets. the riveting quality greatly influences the rupture of the rivet and the sheet. the various parameters affect the quality of this operation. in this paper, the optimization of the parameters contributing to the riveting qu...

Dichloroacetate (DCA) is a simple and small anticancer drug that arouses the activity of the enzyme pyruvate dehydrogenase (PDH) through inhibition of the enzyme pyruvate dehydrogenase kinases (PDK1-4). DCA can selectively promote mitochondria-regulated apoptosis, depolarizing the hyperpolarized inner mitochondrial membrane potential to normal levels, inhibit tumor growth and reduce proliferati...

Dichloroacetate (DCA) is a simple and small anticancer drug that arouses the activity of the enzyme pyruvate dehydrogenase (PDH) through inhibition of the enzyme pyruvate dehydrogenase kinases (PDK1-4). DCA can selectively promote mitochondria-regulated apoptosis, depolarizing the hyperpolarized inner mitochondrial membrane potential to normal levels, inhibit tumor growth and reduce proliferati...

ardekoul fault zone which is along nnw-sse is located in eastern iran and northern part of the sistan subzone. dextral strike-slip fault zone of ardekuol is made of six main segments including korizan (28 km), bohn abad (8.8 km), abiz (32 km), gazkoon (20 km), moein abad (30.4 km), ghal maran (12 km), and two minor segments including olang morgh (12.8 km) and seh pestan (9.6 km).  the studied r...

data related to holstein dairy cattle from 1987 to 2004 were obtained from animal breeding center of iran to estimate the genetic and phenotypic trends. variance components and genetic parameters of the first lactation records were estimated using restricted maximum likelihood method and aireml algorithm through matvec program. animal breeding values were predicted through multiple-trait animal...

because of high cost of drilling and analysis of samples, it needs to predict gold and silvers based on pathfinder such as as, sb, cd, pb and zn and decrease the cost and time exploration project implementation. in this paper, the model based on a multilayer perceptron artificial neural network (mlp-ann) optimized by invasive weed optimization algorithm (iwo) to predict of gold and silver in za...