Objective(s):Experimental allergic encephalomyelitis (EAE) is an autoimmune disease validated as animal model of multiple sclerosis (MS). Administration of genistein, a phytoestrogenic component of soy, to mice at the onset of EAE is known to attenuate the clinical signs of the disease. The potential effects of genistein on established EAE is less studied. In the current study, we aimed to comp...

Objective: The aim of this study was to investigate the effect of Resistance Training (RT) with Genistein on Interleukin-6 (IL-6) and C-reactive protein (CRP) in diabetic rats. Materials and Methods: 64 induced diabetic rats into 8 groups were investigated with experimental study: first week control, last week control, RT, 15 mg/kg Genistein consumption, resistance exercise with 15 mg/kg Genis...

objective(s): parkinson's disease (pd) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. evidence indicates that pd occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. it is reported that soy genistein, an estrogen agonist phytoestrogen, display neuro...

Objective(s): Parkinson's disease (PD) is a progressive neurological disorder associated with motor disabilities and cognitive dysfunction as well. Evidence indicates that PD occurs less frequently in women than men, confirming a role for steroid hormones in protection of dopaminergic nigrostriatal neurons. It is reported that soy genistein, an estrogen agonist phytoestrogen, display neuroprote...

Objective: The purpose of this study was to investigate the effect of moderate and high intensity endurance trainings with genistein consumption on tumor necrosis factor alpha (TNF- α) and interferon gamma (INF- γ) in streptozotocin induced diabetic rats. Materials and Methods: In this experimental study, 64 male diabetic rats were randomly assigned into 8 groups of 8 (1) first week control (2...

Objective(s): Genistein is reported to have anti-diabetic and anti-inflammatory functions, in particular, direct effects on β-cell proliferation and insulin secretion. In this study, we investigated the anti-inflammatory effect of genistein on the pancreatic β-cells in ovariectomized diabetic rat. Materials and Methods:Forty female rats were divided into four groups: sham, bilateral ovariectomy...

objective(s):experimental allergic encephalomyelitis (eae) is an autoimmune disease validated as animal model of multiple sclerosis (ms). administration of genistein, a phytoestrogenic component of soy, to mice at the onset of eae is known to attenuate the clinical signs of the disease. the potential effects of genistein on established eae is less studied. in the current study, we aimed to comp...

to study the effect of planting dates and genistein application on nitrogen content and nodulation of three annual medic species (medicago polymorpha cv. santiago m. rigidula cv. ragidula, and m. radiata cv. radiata), an experiment was conducted during 2005-2006 in the research farm of faculty of agriculture, shahed university, tehran. the treatments were arranged as split split plot in a rando...

Objective(s): The role of isoflavones in pulmonary structure and function during menopause is not well studied. Moreover, the important role of estrogen in the physiological function of respiratory system has been revealed. Genistein, as an isoflavone, mimics estrogenic in diabetic and ovariectomized rats. Here, we hypothesized that genistein would reverse changes in the protein expression leve...

Soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and anti-proliferative effects have been studied in different cancer cells. However, the mechanisms of action of genistein and its molecular targets on human colon cells have not been fully elucidated. Therefore, caspase-3 and p38 mitogen-activated protein kinase (p38 MAPK) as the main therapeutic targets...