The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liqui...

The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liqui...

ammonia is the chief excretory product in fishes. however, non-availability of enough of water in the habitat, may lead to the formation of urea, in fishes. in the present study, the possible role of urea formation to avoid the toxicity of ammonia under water-restricted condition was tested in channa gachua. circulatory urea and ammonia were estimated in the blood of the fishes and glutamate de...

The objective of the study was to evaluate effects glutamine and glutamate (Gln/Glu) on growth performance immune response nursery pigs fed different digestible lysine content. Two hundred sixteen piglets, weaned at 21 days old, were assigned a randomized block design according their initial body weight (BW), in 2 × factorial arrangement with two levels (control-lys low-lys) Gln/Glu (0 12 g kg-...

Serum urea concentrations were measured in Large White pigs from lines divergently selected for components of efficient lean growth rate and performance tested over three 14-d test periods starting at 30, 50, and 75 kg. Two methods of performance testing were used. Phase-fed pigs were fed to appetite isoenergetic diets differing in total lysine:energy ratio (0.58, 0.69, 0.81, 0.91, 1.01, 1.12, ...

Fishes, in general, follow ammonotelic mode of excretion. However, certain stress factors may provoke them to excrete urea. In the present study, the possible role of ureogenesis to avoid accumulation of toxic ammonia under water-restricted condition was tested in Heteropneustes fossilis. A total of hundred fishes were collected and sacrificed. Excretory urea and ammonia were estimated in the w...

1. Four pregnant sows were used to study lysine requirements by means of the interpretation of values for plasma amino acid and blood urea. Diets containing graded levels of dietary lysine were fed at the rate of 1.82 kg/d. 2. Plasma lysine remained at a low level up to 6.4 g dietary lysine/kg (dry matter basis) and then increased sharply with further increases in lysine intake. 3. Blood urea l...

Ammonia is the chief excretory product in fishes. However, non-availability of enough of water in the habitat, may lead to the formation of urea, in fishes. In the present study, the possible role of urea formation to avoid the toxicity of ammonia under water-restricted condition was tested in Channa gachua. Circulatory urea and ammonia were estimated in the blood of the fishes and glu...

Ammonia is the chief excretory product in fishes. However, non-availability of enough of water in the habitat, may lead to the formation of urea, in fishes. In the present study, the possible role of urea formation to avoid the toxicity of ammonia under water-restricted condition was tested in Channa gachua. Circulatory urea and ammonia were estimated in the blood of the fishes and glu...

The dietary lysine requirement of adult sows nursing 10 pigs was estimated by using plasma urea nitrogen (PUN) concentration as a rapid response criterion. A preliminary experiment indicated that a 3-d feeding time is required to re-equilibrate PUN concentrations after a change in the dietary concentration of lysine. In the main experiment, 12 sows (BW = 219 +/- 5 kg; parity = 4.5 +/- .3; ultra...