HIV-1 Circulating Recombinant Form 35_AD (CRF35_AD) has an important position in the epidemiological profile of Afghanistan and Iran. Despite the presence of this clade in Afghanistan and Iran for over a decade, our understanding of its origin and dissemination patterns is limited. In this study, we performed a Bayesian phylogeographic analysis to reconstruct the spatio-temporal dispersion patt...

We conducted this study to obtain a comprehensive picture of molecular epidemiology of HIV-1 in three neighboring countries, i.e. Afghanistan, Iran, and Pakistan as a basis for discussing possible hypothesis regarding between-country virus transmission. Our results showed that subtype composition differs between these countries with more variation in Pakistan than Iran and Afghanistan. The CRF3...

we conducted this study to obtain a comprehensive picture of molecular epidemiology of hiv-1 in three neighboring countries, i.e. afghanistan, iran, and pakistan as a basis for discussing possible hypothesis regarding between-country virus transmission. our results showed that subtype composition differs between these countries with more variation in pakistan than iran and afghanistan. the crf3...

A national ART program was launched in Tanzania in October 2004. Due to the existence of multiple HIV-1 subtypes and recombinant viruses co-circulating in Tanzania, it is important to monitor rates of drug resistance. The present study determined the prevalence of HIV-1 drug resistance mutations among ART-naive female bar and hotel workers, a high-risk population for HIV-1 infection in Moshi, T...

Editor: Human immunodeficiency virus type 1 (HIV-1) is known for its remarkable genomic variability due to (1) the error-prone nature of the reverse transcriptase (RT), which has no proofreading ability and can generate nucleotide substitutions, deletions, and=or substitutions as well as to (2) recombination between different HIV-1 strains. HIV-1 has been classified into three groups: M (major)...

Little information is available regarding a circulating HIV genotype among high-risk groups in Afghanistan; we describe HIV genotypes among injecting drug users (IDUs) and sex workers (SWs) in four Afghan cities. Participants completed behavioral questionnaires and HIV testing. Western blot-confirmed specimens had peripheral mononuclear blood cells isolated for genotyping. Analysis of recombina...

background human immunodeficiency virus (hiv)-1 infection is one of the most important infectious diseases in iran, and common isolates belong to the new crf35_ad subtypes. the gp120 protein, which is located on the surface of the hiv envelope, plays a role in entrance into host cells and immune responses. as there isn’t any clear analysis of the envelope protein of iranian isolates regarding p...

OBJECTIVE Drug-resistant (DR) HIV emerges during combined antiretroviral treatment (cART), creating concern about widespread transmission of DR-HIV as cART is expanded in resource-limited countries. The aim of this study was to determine the predominant HIV-1 subtypes and prevalence of transmitted DR mutations among antiretroviral-naïve patients in Iran. DESIGN To monitor transmission of DR H...

The distribution of HIV-1 subtypes in a population tracks the spread and evolution of the epidemic. This study is a systematic review of all available evidence on HIV-1 molecular epidemiology and subtype distribution in the Middle East and North Africa. Sources of data included Medline and various institutional documents and databases. In several countries, a diverse distribution of HIV-1 subty...