background: cervical cancer is the second most common cancer in the world among women and human papilloma virus (hpv) plays a major role in its development. the aim of this study was to determine the frequency of hpv type 16 and 18 in cervical discharge by polymerase chain reaction (pcr) method in women with atypical biopsy or papsmear. method: this case- control study was performed on women i...

background and objectives: some of the human papillomaviruses (hpvs) can infect genital tracts and are sometimes associated with anogenital tract cancers. hpvs induced cervical cancers through the expression of e6 and e7 genes by inactivating the tumor suppressor proteins. in this study, e6 and e7 genes were chosen in order to construct an expression vector which is able to express target prote...

Background and Aim: Determination of HPV genotypes in cervical lesions is essential in screening programs and the impact of current HPV vaccines. Therefore, we investigated the frequency of various HPV genotypes among different grades of cervical lesions. Materials and Methods: In total, 101 biopsy samples of different grades of cervical lesions were collected. Extracted DNA was subjected to P...

  Background: Cervical cancer is the second most common cancer in the world among women and human papilloma virus (HPV) plays a major role in its development. The aim of this study was to determine the frequency of HPV type 16 and 18 in cervical discharge by polymerase chain reaction (PCR) method in women with atypical biopsy or papsmear. Method: This case- control study was performed on wome...

background: this study was performed to compare the prevalence of hpv infection and high risk hpv genotypes [16, 18] between monogamous and polygamous women, in zabol, iran. methods:   this cross sectional study was conducted in zabol in 2006 - 2007. two hundred sixty five married women attend­ing the gynecology clinic for cervical disease screening entered to this study. one hundred sixty two ...

This observer-blind study (clinicaltrials.gov NCT01462357) compared the immunogenicity and safety of 2 doses of the HPV-16/18 AS04-adjuvanted vaccine (HPV-16/18(2D)) vs. 2 or 3 doses of the HPV-6/11/16/18 vaccine (HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D)) in healthy girls aged 9-14 y. Girls were randomized (1:1:1) to receive HPV-16/18(2D) at months (M) 0,6 (N = 359), HPV-6/11/16/18(2D) at M0,6...

Background: The pathogenesis of endometriosis is still debatable, and many studies reported a predisposition to infectious immunological factors. In this study, we aimed evaluate the human papillomavirus (HPV) positivity in pain-related symptoms infertility. Methods: cross-sectional 410 patients were enrolled study. HPV-positive (n = 202) HPV-negative 208) compared with symptoms, infertility, e...

To understand human papillomavirus type 16 (HPV-16) gene regulation, it is necessary to understand HPV-16 RNA processing. HPV-16 encodes multiple 5'- and 3'-splice sites and two polyadenylation signals pAE and pAL (Figure 1). The major 3'-splice site on the HPV-16 genome (SA3358) is used for generation of E6, E7, E4, L1 and L2 mRNAs. It encodes a suboptimal splice signal but is under control of...