objective(s):diabetes plays an important role in the induction of the liver injury. grape seed proanthocyanidin (gsp) have a wide range of medicinal properties against oxidative stress. in this study we evaluated antioxidant effects of gsp on liver in streptozotocin-induced diabetic rats. materials and methods: thirty male sprague–dawley rats were divided into three groups: control, untreated d...

the purpose of this study was to examine the acute and sub-acute effects of diazinon onhistopathological parameters of liver tissue and blood level of hepatic enzymes of male commonfrog (rana ridibunda). frogs were assigned to 9 groups (n=8, meaning 8 frogs in each group):control and treatment groups with 30, 60, 90 and 120 μg/l diazinon in water for one day or oneweek. hepatic enzymes containi...

severe hepatic failure accounts for many deaths and raises medical costs each year worldwide. currently, liver transplantation is the most common therapeutic option for patients with end-stage chronic liver disease. due to decrease in the number of organ donors, many in need of transplantation continue to remain on the waiting list. hepatic tissue engineering is a step toward alleviating the ne...

objective: micrornas (mirnas) are noncoding rnas that function as key regulators of diverse biological activities such as cellular metabolism, cell proliferation and cell cycle regulation. recent studies have indicated the high potential of these small molecules to control stem cell differentiation into desired cells. the aim of present study is to investigate the possible effect of let-7f on e...

Background: Hepatic ischemia/reperfusion injury (I/RI) is a multifactorial pathophysiologic process which can lead to liver damage and dysfunction. This study examined the protective effect of dexamethasone on the gene expression of endothelial nitric oxide synthase (eNOS) and endothelin-1 (ET-1) and on the liver tissue damage during warm hepatic I/R. Materials and Methods: A total of 32 mal...

i have carried out 22 biopsies in 20 patients, in fifteen i used a vim _ silverman needle, and in the remainder a curetting type needle, in 12 cases (60%) the diagnosis that was made; in 3 cases, inadequate tissue, was obtained; in two cases a fibromuscular tissue, in one case a fatty tissue and in one case the specimen was of hepatic tissue. even with the small biopsy specimen obtained with th...

background: hepatic ischemia/reperfusion injury (i/ri) is a multifactorial pathophysiologic process which can lead to liver damage and dysfunction. this study examined the protective effect of dexamethasone on the gene expression of endothelial nitric oxide synthase (enos) and endothelin-1 (et-1) and on the liver tissue damage during warm hepatic i/r. methods: a total of 32 male wistar rats was...

background adipose tissue mesenchymal stem cells (at-mscs) are suitable choices in treatment of liver associated diseases. dimethyl sulfoxide (dmso) is an amphipathic molecule with potential of delivering both lipophilic and hydrophilic agents into cells. few protocols used dmso for induction of at-mscs towards hepatocyte like cells but the effect of dmso on hepatogenic differentiation were not...

Objective: The use of non-enzymatic antioxidants in food supplements and proper exercise can have a positive effect on decreasing oxidative stress by free radical hunting. The purpose of this study was to investigate the effect of aerobic training and L-carnitine supplementation on some of the oxidative stress factors in the liver of diabetic rats. Materials and Methods: In this experimental s...