Two new hexahydropyrimidine compounds were prepared in high yield by condensation of an equimolar amount of 1,3-diamine with 2-dipyridylketone at room temperature in dichloromethane. The desired hexahydropyrimidine structures were confirmed on the basis of their UV-Visible, elemental analysis, FT-IR, 1H-NMR, TG/DTG, and EI-MS ...

Disclosure: Dr Peter Ferenci reports membership of the respective advisory boards for Univar, Wilson Therapeutics, and Vivet Pharmaceuticals. Dr Hirschfield reports personal fees for preparing and delivering an educational seminar from Univar, during the conduct of the study. Outside the submitted work, Dr Hirschfield is on the advisory board (PBC) for Novartis, GSK, Intercept Pharmaceuticals, ...

Copyright © 2005 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX DOI: 10.1161/01.CIR.0000159336.31613.31 2005;111;1530-1536 Circulation Patrick Vallance and Aroon D. Hingorani Stidwill, Mervyn Singer, John E. Deanfield, Raymond J. MacAllister, Mark B. Pepys, Brian ...

VCAM-1 and monocyte adherence in arteries exposed to altered shear stress. Arterioscler Thromb Vasc Biol 1995;15:2–10. 24. Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, Lowe GD, Pepys MB, Gudnason V. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 2004; 350:1387–1397. 25. Tall AR. C-reactive prot...

Hepatocyte growth factor (HGF) is a potent epithelial mitogen whose actions are mediated through its receptor, the proto-oncogene c-Met. Two truncated variants of HGF known as NK1 and NK2 have been reported to be competitive inhibitors of HGF binding to c-Met, and to function as HGF antagonists (Lokker, N.A., and P.J. Godowski. 1993. J. Biol. Chem. 268: 17145-17150; Chan, A.M., J.S. Rubin, D.P....

Hirschfield, Wulf, Melanie R. Moody, William E. O’Brien, Anthony R. Gregg, Robert M. Bryan, Jr., and Michael B. Reid. Nitric oxide release and contractile properties of skeletal muscles from mice deficient in type III NOS. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R95–R100, 2000.—Skeletal muscle constitutively expresses both the type I (neuronal) and type III (endothelial) isof...

This paper reviews a series of public sector applications of the Super Profiles geodemographic typology that was produced using data derived from the 1991 Census. The applications, often in combination with the use of GIS software, have emerged in work undertaken by the staff of the Urban Research and Policy Evaluation Regional Research Laboratory (URPERRL). Examples of applications are drawn f...