نتایج جستجو برای: Histamine receptor antagonists
تعداد نتایج: 624443 فیلتر نتایج به سال:
objective: the nucleus accumbens (nac) receive histaminergic neurons from tuberomammillary nuclei. there are reports indicating that central histamine systems are involved in many physiological behavioral processes, including anxiety. the aim of the present study was to assess whether the histaminergic system of the nac is involved in anxiety-related behaviors. methods: rats were anesthet...
objective(s): the present study investigated the effects of microinjection of histamine and histamine h1, h2, and h3 receptor antagonists, chlorpheniramine, ranitidine and thioperamide, respectively into the primary somatosensory cortex (psc) on inflammatory pain. material and methods: two stainless steel guide canulas were bilaterally implanted into the psc of anaesthetized rats. inflammator...
Background and purpose: Histamine is a neurotransmitter present in the brain of mammals which produces its physiological effects on target cells by stimulation of three types of receptors H1, H2 and H3. Various reports nowadays indicate the role of histamine in reduction of pain transmission. This study was designed to determine the role of histamine receptors in reduction of pain. Mate...
Background and purpose: Repetitive licking behaviour is a stereotyped phenomenon that is correlated with activation of the nigrostriatal system, and is thought to be produced by activation of both postsynaptic dopamine D1 and D2 receptors. There are good evidences showing that the histaminergic mechanisms may be closely related to dopaminergic systems, and play an important modulatory role in...
The main objective of this study was to investigate the ability of histamine receptor antagonists to modulate tryptase release from human colon mast cells induced by histamine. Enzymatically dispersed cells from human colon were challenged with histamine in the absence or presence of the histamine receptor antagonists, and the tryptase release was determined. It was found that histamine induced...
Background and purpose: Sedation is regarded as a common side effect of most antihistamines, and limits the clinical utility of classical antihistaminic agents, while newer antihistamines are nonsedating. Çonsidering the importance of this phenomenon in the present study, the role of different histamine receptor mechanisms in mediating the sedation were investigated in rat rota rod test. M...
Using specific histamine H1 and H2 receptor antagonists, evidence is presented for the existence of both H1 and H2 receptors on human articular chondrocytes in vitro. Stimulation of the H1 receptor by histamine (range 0.18 to 17.8 mumol/l) significantly increased prostaglandin E (PGE) production, while activation of the histamine H2 receptor increased intracellular cyclic adenosine-5'-monophosp...
With the very recent market approval of pitolisant (Wakix®), the interest in clinical applications of novel multifunctional histamine H3 receptor antagonists has clearly increased. Since histamine H3 receptor antagonists in clinical development have been tested for a variety of different indications, the combination of pharmacological properties in one molecule for improved pharmacological effe...
Modification of the cardiac rhythm by histamine has been appreciated almost since the compound's isolation from ergot by Barger and Dale in 1910. The major arrhythmogenic actions of histamine are an Hi-receptor-mediated slowing of atriovenrricular (AV) conduction and H2-receptor-mediated increases in sinus rate and ventricular automaticity. These actions were elucidated by observing the salutar...
Modification of the cardiac rhythm by histamine has been appreciated almost since the compound's isolation from ergot by Barger and Dale in 1910. The major arrhythmogenic actions of histamine are an Hi-receptor-mediated slowing of atriovenrricular (AV) conduction and H2-receptor-mediated increases in sinus rate and ventricular automaticity. These actions were elucidated by observing the salutar...
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