نتایج جستجو برای: Ketamine, 1-Tetralone derivatives

تعداد نتایج: 2839312  

2013
Brian M Casey Dhandapani V Sadasivam Robert A Flowers II

The synthesis of 2-tetralones through the cyclization of δ-aryl-β-dicarbonyl substrates by using CAN is described. Appropriately functionalized aromatic substrates undergo intramolecular cyclizations generating 2-tetralone derivatives in moderate to good yields. DFT computational studies indicate that successful formation of 2-tetralones from δ-aryl-β-dicarbonyl radicals is dependent on the sta...

Journal: :Molecules 2013
Hassan M Faidallah Khalid M A Al-Shaikh Tariq R Sobahi Khalid A Khan Abdullah M Asiri

An efficient and novel method for the synthesis in moderate to good yield (72%-84%) of a series of 3-amino-1-substituted-9,10-dihydrophenanthrene-2,4-dicarbonitriles 1-5 via one-pot multi-component reactions of aldehydes, malononitrile, 1-tetralone and ammonium acetate has been delineated. Cyclocondensation attempts of aminocyanophenanthrene derivatives 1, 2, 4 and 5 with acetic anhydride in th...

2013
Xu-Hua Nong Zhi-Hui Zheng Xiao-Yong Zhang Xin-Hua Lu Shu-Hua Qi

Eighteen polyketides (1-18) including six citrinin derivatives, two phenol derivatives, one cyclopentenone, two naphthol derivatives, and seven tetralone derivatives were isolated from the culture broth of a marine-derived fungal strain Xylariaceae sp. SCSGAF0086. Five of these compounds (1, 2, 8, 9, and 10) were new, and their structures were determined by spectroscopic methods. Compounds 4, 6...

Journal: :Molecules 2012
Jae-Chul Jung Eunyoung Lim Yongnam Lee Dongguk Min Jeremy Ricci Oe-Sook Park Mankil Jung

The total synthesis and structure determination of cis- and trans-flocoumafen was described. The key synthetic steps involve Knoevenagel condensation with p-methoxybenzaldehyde, in situ decarboxylation and intramolecular ring cyclization to construct the tetralone skeleton. Stereospecific reduction of the O-alkylated ketone 13 afforded good yield of precusor alcohol 5. Final coupling of alcohol...

Journal: :iranian journal of pharmaceutical research 0
abbas ahmadi department of chemistry, faculty of science, islamic azad university, karaj branch, karaj, iran. ramin hajikhani department of chemistry, faculty of science, islamic azad university, karaj branch, karaj, iran. leila barghi department of chemistry, faculty of science, islamic azad university, karaj branch, karaj, iran. farnaz mihandoust department of chemistry, faculty of science, islamic azad university, karaj branch, karaj, iran. mohsen khalili department of physiology, school of medicine, shahed university, tehran, iran.

phencyclidine (1-(1-phenylcyclohexyl) piperidine, pcp, i) and ketamine (2-o-chlorophenyl-2-methylaminocyclohexan, ii) have shown analgesic effects. some of its derivatives were synthesized and their biological properties have been studied. in this study, a new derivative of pcp, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, pcp-och3-tetralyl, iii) was synthesized and the acute thermal pain of...

Abbas Ahmadi, Farnaz Mihandoust Leila Barghi Mohsen Khalili, Ramin Hajikhani,

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain ...

Abbas Ahmadi, Farnaz Mihandoust Leila Barghi Mohsen Khalili, Ramin Hajikhani,

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain ...

Journal: :Angewandte Chemie 2021

Atropo-enantioselective biaryl coupling through C−H bond functionalization is an emerging technology allowing direct construction of axially chiral molecules. This approach largely limited to electrophilic partners. We report a highly atropo-enantioselective arylation tetralone derivatives paired with aryl boronic esters as nucleophilic components. The transformation catalyzed by cyclopentadien...

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