background: cadmium is one of the most toxic heavy metals in our environment having a very strong ability to accumulate in body organs, especially in kidney. the present study was done to determine the genotoxicity and cytotoxicity in kidneys of rats exposed to cadmium. methods: male rats (n=30), kept in standard conditions were used in this study. the animals were randomly divided into 2 group...

Objective(s): The current study was designed to investigate the therapeutic and protective effects of montelukast (ML) against doxorubicin (DOX)-induced acute kidney damage in rats.Materials and Methods: Thirty-five Wistar albino female rats were randomly divided into 5 groups as follows: Group I: Control; Group II: Control+ML; Group III: DOX; Group IV: DOX+ML; Group V: ML+DOX. At the end of th...

normal 0 false false false en-us x-none ar-sa background: cisplatin (cis-diamminedichloroplatinum ii; cp) is used widely as an antitumor drug in clinics, but is accompanied with renal toxicity. cisplatin induced nephrotoxicity consists of change in kidney weight, histological changes in kidney and increase in serum creatinine (cr) and blood urea nitrogen (bun). this study was designed to find o...

The angiotensin I-converting enzyme (ACE) converts the inactive angiotensin I molecule to the active angiotensin II. ACE is rich in epithelium, endothelium, and neuroepithelial cells and it found largely on the brush border of intestine and kidney proximal tubules. ACE also presents in the serum. Some pulmonary and renal toxic drugs change the serum and tissue ACE contents. In this research ACE...

This study was conducted to evaluate the tissue of liver, gills and kidney Rutillus caspicus exposed to concentrations of 50, 100, 150 mg of Methyl tert-butyl ether, for 7, 14, 21 days. Average water temperature of 19±1 °C, water oxygen of 7.6 ± 0.2 mg/l and zero salinity were measured. A total of 156 fishes were studied in this experiment. In the first, second and third week of the test, three...

Background & Aims: There are several reports about anti-oxidant effects of garlic in the literature. In this study the effect of garlic alcoholic-water extract on the treatment of lead-induced toxicity in kidney of neonatal rat and the protective effect of garlic alcoholic water extract on body and kidney weight and also kidney tissue were investigated. Method: Neonatal rats were divided in...

background: acute kidney injury (aki) has been recognized as one of the most complex clinical complications in modern medicine, and ischemia/reperfusion (i/r) injury is well-known as a main reason of aki. in addition, aki leads to important systemic consequences such as acute lung injury. this study was designed to investigate the role of erythropoietin (epo) on kidney function makers and tissu...