background: diazinon (dzn) is an organophosphate insecticide which is used worldwide in agriculture. the exposure to this chemical might lead to damages to the living systems. objective: the present study was done to investigate the effects of diazinon on the structure of testis and levels of sex hormones in adult male mice. materials and methods: for this experiment, the mature male mice divid...

unilateral orchidectomy (uo) is required when further breeding potential is important. it is sometimes necessary to remove a single testis in a matured stallion for therapeutic reasons. in this study, twelve donkeys were used to evaluate three techniques of unilateral castration, histological and morphological changes on the remaining testis. results of the study showed that each of the surgica...

Background: Hyperprolactinemia is a particular concern in the treatment of schizophrenic patients. The side effects associated with high prolactin levels can have a negative impact on GnRH pulsatile secretion and, consequently LH, FSH and testosterone pulsatility and follows by, on special testicular cells that have these hormon’s receptors such as sertoli and leydig cells. Quantification the d...

background: nano-particles are extensively employed in most industries. several studies have been started to explore the probable detrimental effects of nano-particles on human reproduction. however, there is insufficient and controversially evident of effects of silver nano-particles on sperm parameters and other reproductive indices. objective: investigation of the effects of silver nano-part...

Leydig cells are the primary source of androgens in the mammalian testis. It is established that the luteinizing hormone (LH) produced by the anterior pituitary is required to maintain the structure and function of the Leydig cells in the postnatal testis. Until recent years, a role by the thyroid hormones on Leydig cells was not documented. It is evident now that thyroid hormones perform many ...

The investigation was conducted to elucidate seasonal histomorphological changes of Leydig cells in Japanese Jungle crows (Corvus macrorhynchos). All adult crows (n=12) were killed for H&E staining. Histologic data of Leydig cells regarding their locations in the interstitium, appearance and disappearance of lipoidal materials in their cytoplasm, precursor cells and fibroblasts are studied. In ...

The aim of this study is to examine the influence of Sertoli cells on LH binding to Leydig cells in culture in immature mice. Leydig cells and Sertoli cells were obtained from the testes of immature C57BL/6Ncrj mice and were cultured in serum-free medium for 7 days. The LH binding to Leydig cells and the FSH binding to Sertoli cells were dependent on incubation time, the number of cells, and th...

Development of the testis begins with the expression of the SRY gene in pre-Sertoli cells. Soon after, testis cords containing Sertoli and germ cells are formed and fetal Leydig cells subsequently develop in the interstitial space. Studies using knockout mice have indicated that multiple genes encoding growth factors and transcription factors are implicated in fetal Leydig cell differentiation....

Aging in Brown Norway rats is associated with reduced Leydig cell T production. To address the mechanism by which aging Leydig cells become steroidogenically hypofunctional, Leydig cells from young and old rat testes were isolated and cultured long-term with LH. Leydig cells isolated from young rats that had received LH-suppressive T implants served as positive controls. The ability of young co...

By means of immunocytochemical methods, immunoreactivity for the brain isoform of nitric oxide synthase (NOS-I) was recognized in numerous Leydig cells of the human testis as well as in MA-10 tumor and TM3 non-tumor mouse Leydig cell lines. Within the Leydig cell cytoplasm, immunocytochemical results suggested the occurrence of factors known to activate NOS-I such as glutamate and aspartate, as...