This research work examines and verifies the use of subchromosome representations previously introduced to the linkage learning genetic algorithm (LLGA). The subchromosome representation is utilized for effectively lowering the number of building blocks in order to escape from the performance limit implied by the convergence time model for the linkage learning genetic algorithm. A preliminary i...

Genetic association analysis using thousands of single nucleotide polymorphism (SNP) markers has become a promising alternative to genome-wide linkage scan. Analysis based on linkage-disequilibrium (LD) is more efficient because meiotic information of past generations is utilized. However, in addition to the physical distance between the disease locus and a marker locus, numerous other factors ...

OBJECTIVE Type 1 diabetes arises from the actions of multiple genetic and environmental risk factors. Considerable success at identifying common genetic variants that contribute to type 1 diabetes risk has come from genetic association (primarily case-control) studies. However, such studies have limited power to detect genes containing multiple rare variants that contribute significantly to dis...

This report investigates the use of Linkage Learning in Genetic Algorithms (GAs) to try and determine why it is worthwhile using this technique to improve the power of GAs. This report first introduces GAs and how they go about converging on optimal solutions with comparison to other search algorithms. Then it discusses what linkage learning is and several of the techniques used to perform link...

This paper presents a synthesis procedure for a spatial 4R linkage, known as Bennett’s linkage. It is known that the two solutions of the RR chain synthesis equations form a Bennett linkage. While analytical solutions to these equations have been developed previously, this paper uses the cylindroid that is known to exist for a Bennett linkage to simplify the solution process. It is interesting ...

The first phase work of the project involving the conceptualization of mechanical design of an active knee prosthesis linkage mechanism is proposed in this paper. For patients needing limb movement rehabilitation with impaired upper or lower limb joint functions and also for otherwise healthy persons suffering muscle weakness syndrome, this paper proposes an active linkage mechanism along with ...