background: chemical toxins are among the leading causes of liver disorders, inflammation and necrosis in hepatocytes. the aim of this study was to evaluate of protective effect of hydroalcoholic extract from rhizome of zingiber officinale l. (hez) on carbon tetrachloride-induced hepatic injury in male rat. material and methods: in this experimental studymale wistar rats (n=35, body weight 230-...

background and aims: urtica dioica as a medicinal herb due to its anti-inflammatory, antioxidant and hypoglycemic effects, improve type 2 diabetes and decrease inflammation, fibrosis and necrosis as the signs of nonalcoholic steatohepatitis. polycystic ovary syndrome (pcos) as the most important factor of infertility has an overlap of 30 % to 60% with liver disorders. hence, the urtica dioica m...

2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) is a by-product o f t he trichlorophenol (herbicide) production and is also produced through a variety of combustion processes. it appears that tcdd is a ubiquitous chemical, particularly in industrialised countries, and the liver is the target organ of its toxicity. the prominent hepatotoxic effect of tcdd is progressive centrilobular necrosis. the is...

copper (cu) is an essential trace element involved in normal reproduction but its over-exposure may produce some detrimental effects. the aim of this study was to investigate the effects of purslane on copper sulfate poisoning on liver structures changes. twenty eight wistar rats were randomly allocated to four treatment groups. group i) control, group ii) copper sulfate (200 mg/kg bw were appl...

The occurrence of hepatotoxicity following etanercept (tumor necrosis factor-alpha antagonist) prescription, has been studied well. However, an acute hepatic failure leading to liver transplant as an adverse effect of this drug has not been reported in the literature. In this article, we are going to present a case of acute liver failure followed by liver transplantation, in a 32 years old man ...

Background: Mesenchymal stem cells (MSCs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. However, the low survival rate of these cells restricts their therapeutic applications. It is hypothesized that autophagy might play an important role in cellular homeostasis and survival. This study aims to investigate the regenerative potentia...

Background: Hepatitis activity index (HAI) and fibrosing stage are two important findings during the evaluation of liver samples in patients with chronic hepatitis B. The aim of this study was to determine the HAI and fibrosing stage in patients with anti-HBe positive chronic hepatitis B. Methods: Liver biopsy slides of 72 patients were evaluated at the Department of Pathology in two teaching ...

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a by-product o f t he trichlorophenol (herbicide) production and is also produced through a variety of combustion processes. It appears that TCDD is a ubiquitous chemical, particularly in industrialised countries, and the liver is the target organ of its toxicity. The prominent hepatotoxic effect of TCDD is progressive centrilobular necrosis. Th...