conclusion ct scan is highly accurate in differentiating malignant pleural mesothelioma and metastatic pleural diseases. pleural thickening and thickening of interlobar fissure lead us to the diagnosis of mpm and massive free pleural effusion is more commonly seen in metastatic pleural malignancy. background malignant pleural mesothelioma (mpm) is a rare malignant neoplasm of the pleura that ty...

a spectrophotometric method for selective complexation reaction and simultaneous determination of mycophenolate mofetil (mpm), and mycophenolic acid (mpa) using three multivariate chemometric methods, i.e. partial least squares regression, principal component regression and principal component artificial neural networks, is proposed. the method is based on the complexation reaction of mpm and m...

background malignant pleural mesothelioma (mpm) is an uncommon neoplasm. mpm occurs more frequently in patients born or living in certain villages of turkey. objectives we aimed to review radiological findings of mpm. patients and methods we reviewed the ct findings in 219 biopsy-proven mpm patients admitted to our clinic between 1993 and 2008. results the most common ct findings included pleur...

Accurate diagnosis of malignant pleura mesothelioma (MPM) is challenging. Differential diagnosis of MPM versus lung adenocarcinoma (AD) is particularly difficult, yet clinically important since the two neoplasias call for different treatment approaches. Circulating miRNA-profiling to identify miRNAs that can be used to distinguish MPM from AD has not been reported. We conducted a wide screening...

PURPOSE Mesothelin (MSLN) is a tumor-associated antigen, being investigated as a biomarker and therapeutic target in malignant pleural mesothelioma (MPM). The biologic function of MSLN overexpression in MPM is unknown. We hypothesized that MSLN may promote tumor invasion in MPM, a tumor characterized primarily by regional aggressiveness and rare distant metastases. EXPERIMENTAL DESIGN Human a...

OBJECTIVES Integrin-linked kinase (ILK) is an intracellular protein implicated in chronic inflammation and neoplastic transformation. In a recently accomplished pilot study, we showed that ILK can be detected in the serum of patients with benign and malignant chest diseases, including malignant pleural mesothelioma (MPM). Interestingly, average serum ILK concentrations were 10 times higher in M...

BACKGROUND Malignant pleural mesothelioma (MPM) is marked by its difficult diagnosis and poor prognosis. Medical thoracoscopy (MT) is an effective and safe procedure for the diagnosis of exudative pleural effusions and many factors associated with poor prognosis of MPM. We conducted this study to investigate the value of MT for diagnosing of MPM and to identify prognostic factors for MPM patien...

Malignant pleural mesothelioma (MPM) is characterized by dissemination and aggressive growth in the thoracic cavity. Podoplanin (PDPN) is an established diagnostic marker for MPM, but the function of PDPN in MPM is not fully understood. The purpose of this study was to determine the pathogenetic function of PDPN in MPM. Forty-seven of 52 tumors (90%) from Japanese patients with MPM and 3/6 (50%...

Background The current economic constraints cause hospital management to use the available public resources as rationally as possible. At the same time, there is the necessity to improve current scientific knowledge. This is even more relevant in the case of patients with malignant pleural mesothelioma (MPM), given the severity of the disease, its dismal prognosis, and the cost of chemotherapy ...

PURPOSE Mortality Probability Model (MPM) II is a model for predicting mortality probability of patients admitted to ICU. This study was done to test the validity of MPM II for critically ill neurological patients and to determine applicability of MPM II in predicting mortality of neurological ICU patients. METHODS Data were collected from medical records of 187 neurological patients over 18 ...