BACKGROUND:Canine mammary gland cancers are the most prevalent malignancies in dogs. There are different challenges regarding management of these cancers in dogs and human, one hypothesis is related to small cellular subset of tumor mass called cancer stem cell. These cells are therapy resistant and cause metastasis and relapse even after primary successful treatment. The well-identified phenot...

Everybody is born with the mammary gland. Mammary gland development occurs through various stages throughout embryonic, and stays dormant for males. Although it uncommon, male also gets breast cancer, occasionally. Male cancer accounts approximately 1% of all cases, increasing. When compared other rare diseases, understudied. Typically, treated in same way as female cancer. In this article, asp...

Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered fr...

objective: n-nitroso-n-methylurea (nmu) induces breast cancer in rodents, particularly in rats. this model of breast cancer is very similar to human breast cancer. as a continuation of our recent work, we investigated the expressions of cyclin d1 and p21 in nmu-induced breast cancer of wistar albino rats. materials and methods: in this experimental study, mammary carcinoma was induced in female...

b a ckground: the management of internal mammary (im) nodes in breast cancer lacks a well-defined consensus. lymphoscintigraphy identifies up to one-third of breast cancer patients with extra-axillary drainage, which is mainly located in the im chain. our aim in this meta-analysis is to identify the lymphoscintigraphy technique variables that effect im node identification. m ethods: an internet...

despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. recently, human cytomegalovirus (hcmv) was reported as a risk factor for breast cancer. the aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? in this experiment seventeen samples of razi/a mice with spontaneous breast cancer were being gathered fr...

Stinging nettle (Urtica dioica L.,) is a medicinal herb commonly used by humans. The role of reactive oxygen metabolites on cancer etiology is known. There are some studies about the antioxidant effects of Urtica Dioica (UD) on therapy of some cancer types. This study aimed to investigate the effects of UD on antioxidant enzyme activities and mammary gland cancer induced by in rats-N-methyl-N-n...

Stinging nettle (Urtica dioica L.,) is a medicinal herb commonly used by humans. The role of reactive oxygen metabolites on cancer etiology is known. There are some studies about the antioxidant effects of Urtica Dioica (UD) on therapy of some cancer types. This study aimed to investigate the effects of UD on antioxidant enzyme activities and mammary gland cancer induced by in rats-N-methyl-N-n...

Background: Diagnostic molecular marker studies are in vogue to have insight of most prevalent animal diseases including cancer.Objectives: Gene expression profi ling of pro and anti-apoptotic genes was conducted in dog Lymphoma, CTVT, SCC, granuloma, perianal adenocarcinoma and mammary tumors.Materials and Methods: Cancerous tissue...

Introduction: N-nitroso-N-methylurea (NMU) is a carcinogen from nitrosamines family, which has been used to induce breast cancer in rodents. This model of breast cancer is very similar to the estrogen dependent breast cancer in human. As a continuation of our recent works, in the present study, the expressions of both p53 and p27 were investigated in NMU-induced breast cancer in Wistar Albin...