The editors of Metabolites would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016. [...].

solid phase extraction (spe) cartridge embedded with octadecyl c18 chain bounded to silica particles were used for the isolation and trace enrichment of pesticides from water samples collected from cotton, rice growing and municipal areas. the eluents were analyzed with high performance liquid chromatography (hplc) using methanol (100%) as mobiles phase at different uv-visible wavelengths. ddt ...

It is quite evident that microbial (bacteria or fungi) crude extracts contain several important bioactive compounds and some have already shown their therapeutic activity. Unfortunately, most of the compounds have not properly been evaluated for the exploration of new lead molecule. Moreover, some of the mechanisms of actions of few bioactive compounds have not been identified so far. Hence, ex...

a sensitive and rapid method is described for determination of clopidogrel carboxylic acid (cca), the inactive metabolite of the antiplatelet agent clopidogrel in human serum. the analytical procedure involves liquid-liquid extraction of the analyte and an internal standard (phenytoin) with ethyl acetate. a mobile phase consisting of 0.05 m phosphate buffer containing triethylamine (0.5 ml/l; p...

forty renal allograft patients with three months under immunosuppression by cycloserine were examined for their gingival overgrowth and it's correlation with several parameters including the trough levels of blood cyclosporine and it's metabolites measured by the fluorescence polarization immunoassay technique. no correlation was found between the scores of gingival overgrowth and both the age ...

Changes in a patient’s patterns of cocaine use are generally considered an important outcome measure of treatment efficacy. Other treatment outcome measures are important as well, but if a treatment does not stop or significantly decrease the intensity of a cocaine addict’s cocaine use, many would question the treatment’s efficacy. Examination of a patient’s urine for evidence of cocaine or coc...

an experiment was conducted to investigate the effect of different types of ovarian cycles on reproductive indices and blood metabolites in 61 holstein cows. blood samples were taken from each cow between day 12 and day 50 postpartum (pp). serum progesterone concentrations were measured to determine the onset of luteal function and different types of luteal dysfunctions in cows. serum glucose, ...

the objective of this study was to determine the effects of diets having different fermentability on blood gases, blood metabolites and ruminal fermentation parameters in holstein dairy cows. four multiparous holstein dairy cows (665 ± 25 kg bw, 170 ± 7.0 dim and 15±1.5 kg of milk yield), fitted with rumen cannulae, were used in a 4×4 latin square design with 28-d periods. corn starch and sucro...