Mucopolysaccharidoses (MPSs) are a group of metabolic diseases transmitted in an autosomal recessive fashion. MPSs are due to deficiencies of the specific enzymes responsible for the catabolism of dermatan sulfate, heparin sulfate, and keratan sulfate, resulting in the accumulation of glycosaminoglycans (GAGs). MPSs have a chronic, progressive course with multisystemic involvement. The incidenc...

A method based on the multiplex polymerase chain reaction (PCR) and gel electrophoresis for the comparative analysis of gene expression levels was developed. Using the method many cDNA fragments from different sources can be compared simultaneously. Competitive PCR amplification of expressed genes from different sources was performed by using 'module-shuffling primers' (MPSs). The MPSs (labeled...

background abortions are of major public health concern in developing countries. in settings in which abortion is highly prohibited, the direct interview is not a reliable method to estimate the abortion rate. the indirect estimation methods to measure the rate of abortion might overcome this dilemma; they are practical methods to estimate the size of the hidden group who do not agree to partic...

Impaired degradation of glycosaminoglycans (GAGs) with consequent intralysosomal accumulation of undegraded products causes a group of lysosomal storage disorders known as mucopolysaccharidoses (MPSs). Characteristically, MPSs are recognized by increased excretion in urine of partially degraded GAGs which ultimately result in progressive cell, tissue, and organ dysfunction. There are eleven dif...

OBJECTIVE To review of the natural history of airway disease in children with muccopolysaccharidoses (MPSs), which represent a group of hereditary progressive disorders caused by excessive accumulation of glycosaminoglycans in various tissues. DESIGN Retrospective medical chart review. SETTING Tertiary referral academic medical center. PATIENTS Twenty-seven children with MPSs. MAIN OUTC...

Glucocorticoids have a prominent role in the treatment of CNS injuries. However, the cellular consequences of glucocorticoid treatment on remote degenerative responses after focal brain lesions have been poorly investigated. Here we examine the effectiveness of a high dose (50 mg/kg) of methylprednisolone sodium succinate (MPSS) in reducing neuronal loss, glial response and glial-derived inflam...

AIM Spinal Cord Injury (SCI) is routinely treated with standardized methyl prednisolone sodium succinate (MPSS) dose, so it is reassuring to find its effects on liver. We also evaluated the effects of albumin and immunoglobulin G (Ig G) therapies on liver if they are used in case of experimental SCI. MATERIAL AND METHODS The rats were allocated into six groups as control, trauma, vehicle, MPS...

the objective of this paper is to determine the efficiency of manufacturing companies in kenya over the period of 2009 to 2011 as well as suggesting appropriate policies to be employed by the manufacturing companies in kenya based on the findings of the study. three critical inputs variables (raw materials, staff expenses and plant and machinery) and two output variables (net sale and earnings ...

EMIR, M., OZISIK, K., CAGLI, K., OZISIK, P., TUNCER, S., BAKUY, V., YILDIRIM, E., KILINC, K. and GOL, K. Beneficial Effect of Methylprednisolone on Cardiac Myocytes in a Rat Model of Severe Brain Injury. Tohoku J. Exp. Med., 2005, 207 (2), 119-124 ── Cardiac injury, occurred after traumatic brain injury (TBI), has been recognized for more than a century. Bcl-2 is a key regulatory component of t...