Neuropathic pain is a refractory clinical problem. Certain drugs, such as tramadol, proved useful for the treatment of neuropathic pain by inhibiting the activity of nociceptive neurons. Moreover, studies indicated that suppression or modulation of glial activation could prevent or reverse neuropathic pain, for example with the microglia inhibitor minocycline. However, few present clinical ther...

conclusions this case report supports the beneficial role of erythropoietin in function, maintenance, and recovery of neurons. erythropoietin is a double-edge sword, as long-term erythropoietin therapy has some complications, like thromboembolism and stroke. recent studies suggested that erythropoietin should be given as single high dose to exert a rapid neuro-protective effect with minimal hem...

Background Neuropathic pain is a clinical manifestation characterized by the presence of spontaneous pain, hyperalgesia and allodynia. Several works have demonstrated that selective NOS2 inhibitors might reverse the hypersensitivity to pain induced by neuropathy [1,2]. Although these studies suggest a potential role of NOS2 in the modulation of neuropathic pain, the exact involvement of NOS2 in...

Neuropathic pain constitutes a significant portion of chronic pain. Patients with neuropathic pain are usually more heavily burdened than patients with nociceptive pain. They suffer more often from insomnia, anxiety, and depression. Moreover, analgesic medication often has an insufficient effect on neuropathic pain. Spinal cord stimulation constitutes a therapy alternative that, to date, remain...

Optimal assessment of neuropathic pain is crucial for the design and conduct of clinical trials. In recent years, the assessment of neuropathic pain in clinical trials has evolved from crude evaluations of overall pain intensity to a more specific assessment of pain quality and sensory function. Such specific assessment may be relevant to determine sensory profiles of responders to drug or nond...

Neuropathic pain is an integral component of several chronic pain conditions and poses a major health problem worldwide. Despite emerging understanding of mechanisms behind neuropathic pain, the available treatment options are still limited in efficacy or associated with side effects, therefore making it necessary to find viable alternatives. In a genetic screen, we recently identified SerpinA3...

Neuropathic pain frequently affects older people, who generally also have several comorbidities. Elderly patients are often poly-medicated, which increases the risk of drug-drug interactions. These patients, especially those with cognitive problems, may also have restricted communication skills, making pain evaluation difficult and pain treatment challenging. Clinicians and other healthcare pro...

Human brain imaging has revealed that acute pain results from activation of a network of brain regions, including the somatosensory, insular, prefrontal, and cingulate cortices. In contrast, many investigations report little or no alteration in brain activity associated with chronic pain, particularly neuropathic pain. It has been hypothesized that neuropathic pain results from misinterpretatio...

Neuronal damage in the somatosensory system causes intractable chronic neuropathic pain. Plastic changes in sensory neuron excitability are considered the cellular basis of persistent pain. Non-coding microRNAs modulate specific gene translation to impact on diverse cellular functions and their dysregulation causes various diseases. However, their significance in adult neuronal functions and di...