introduction: glial activation and secretion of cytokines at the spinal level is known as part of chronic pain pathogenesis. although changes in tnfα at the supraspinal level are reported during chronic pain, its exact role and site of action remain to be elucidated. we investigated the effect of microinfusion of tnfα into the lc in a rat model of neuropathic pain. methods: male wistar rats wer...

please cite this article as : moini zanjani t, saghaei e, ameli h, sabetkasaei m. anti-allodynic effect of nefopam and morphine in a rat model of neuropathic pain. novel biomed 2013;1:16-22. background: neuropathic pain is a chronic pain due to a disorder in the peripheral or central nervous system with different pathophysiological mechanisms. current treatments are not effective. here we compa...

introduction: neuropathic pain is one of the common complications of diabetes mellitus which is caused by impairment in nerve conductivity. the role of flavonoid and polyphenol compounds in treatment of neuropathic pain has been revealed, and extract of onion contains significant amounts of these compounds. the aim of this study was to investigate the effect of alcoholic extract of onion on dia...

conclusions these results showed enhanced muscle atrophy processes following peripheral nerve damage and might provide a useful approach to study underlying muscle mechanisms associated with clinical neuropathic pain syndromes. results compared to control animals, l5 ligated animals developed mechanical and heat hypersensitivity during total period of study. soleus muscle weight as well as cdk5...

introduction: pharmacological blockage of glial activity has been proved useful for treatment of neuropathic pain by lowering proinflammatory cytokines. the present study is to confirm the effect of post-injury administration of pentoxifylline on chronic constriction injury (cci)-induced neuropathic pain symptoms_ and improved the efficacy of morphine anti-nociception. methods: male wistar rats...

objective(s): neuropathic pain remains a clinical problem and is poorly relieved by conventional analgesics. this study was designed to determine whether maprotiline administration was effective in alleviating symptoms of neuropathic pain and whether the antinociceptive effect of maprotiline mediated through the opioid system. materials and methods: neuropathic pain was induced by chronic const...

conclusions this study demonstrated numerous clinical similarities of trigeminal neuralgia afflicting different populations. right side was more involved along with mandibular division the most commonly affected. however studies needs to be done to know the exact reasons of involvement of the affected side and branches. results the age of the patients varied from 40 to 80 years with a mean age ...

Introduction: Neuropathic pain is one of the common complications of diabetes mellitus which is caused by impairment in nerve conductivity. The role of flavonoid and polyphenol compounds in treatment of neuropathic pain has been revealed, and extract of onion contains significant amounts of these compounds. The aim of this study was to investigate the effect of alcoholic extract of onion on ...