نتایج جستجو برای: RU486

تعداد نتایج: 577  

Journal: :Medicina e Morale 2009

Journal: :international journal of molecular and cellular medicine 0
maryam karami kheirabad department of basic sciences, azad university, gachsaran branch, gachsaran, iran. bahia namavar jahromi infertility research center, department of ob-gyn, school of medicine, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) amin tamadon transgenic technology research center, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) amin ramezani department of medical biotechnology, school of advanced medical sciences and technology, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)سازمان های دیگر: institute of cancer research, shiraz university of medical sciences, shiraz, iran. somayeh ahmadloo infertility research center, department of ob-gyn, school of medicine, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) fatemeh sabet sarvestani infertility research center, department of ob-gyn, school of medicine, shiraz university of medical sciences, shiraz, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences)

the effects of chronic stress and glucocorticoids receptor antagonist (ru486) on expression of melanocortin 4 receptor (mc4r) mrna in arcuate nucleus (arc) of male rats were evaluated. in this study, adult male sprague dawley rats were placed into four groups (n=6/group) stress, ru486, stress/ru486, and control groups. in stress group, the rats were restrained, 1 h/day, for 12 days. in ru486 gr...

Journal: :Vaccines 2021

Trichinellosis is a foodborne zoonotic disease caused by Trichinella spp., including spiralis. In the present study, T. spiralis membrane-associated progesterone receptor component-2 (Ts-MAPRC2) gene was cloned and characterized using protein sequencing analysis. Furthermore, expression, purification, immunoblot assay, binding ability with antibody, immunofluorescence assay were performed. A di...

The effects of chronic stress and glucocorticoids receptor antagonist (RU486) on expression of melanocortin 4 receptor (MC4R) mRNA in arcuate nucleus (ARC) of male rats were evaluated. In this study, adult male Sprague Dawley rats were placed into four groups (n=6/group) stress, RU486, stress/RU486, and control groups. In stress group, the rats were restrained, 1 h/day, for 12 days. In RU486 gr...

A Tamadon B Namavar Jahromi F Rahmanifar M Karami Kheirabad, M Owjfard O Koohi-Hosseinabadi

Background Male fertility and reproduction can affect by stress. The means by which stress influences reproduction is not clearly understood. The aim of the present study was to examine, using stereological methods, the role of glucocorticoids during chronic restraint stress on spermatogenesis. MaterialsAndMethods Twenty four male adult Sprague- Dawley rats were allocated to four equal groups; ...

Journal: :Antimicrobial agents and chemotherapy 2008
Hiroyuki Yamaguchi Shigeru Kamiya Tomonori Uruma Takako Osaki Haruhiko Taguchi Tomoko Hanawa Minoru Fukuda Hayato Kawakami Hajime Goto Herman Friedman Yoshimasa Yamamoto

Since steroids are powerful anti-inflammatory agents and increase susceptibility to a variety of infections, including Chlamydia (Chlamydophila) pneumoniae respiratory tract infections, the effect of the steroid receptor antagonist RU486 (mifepristone) on C. pneumoniae growth in epithelial HEp-2 cells was examined. Treatment of HEp-2 cells with RU486 significantly inhibited the growth of C. pne...

Journal: :Molecular pharmacology 2001
B P Davidson S C Dogra B K May

The cytochrome P450 gene CYP2H1 is highly induced by phenobarbital in chick embryo hepatocytes. Recent studies have established that the orphan nuclear receptor CAR plays a critical role in the induction mechanism. Here, we show that a high concentration of the potent glucocorticoid and progesterone receptor antagonist RU486 almost completely blocks phenobarbital-induced accumulation of CYP2H1 ...

2015
Maryam Karami Kheirabad Bahia Namavar Jahromi Amin Tamadon Amin Ramezani Somayeh Ahmadloo Fatemeh Sabet Sarvestan Omid Koohi-Hosseinabadi

The effects of chronic stress and glucocorticoids receptor antagonist (RU486) on expression of melanocortin 4 receptor (MC4R) mRNA in arcuate nucleus (ARC) of male rats were evaluated. In this study, adult male Sprague Dawley rats were placed into four groups (n=6/group); stress, RU486, stress/RU486, and control groups. In stress group, the rats were restrained, 1 h/day, for 12 days. In RU486 g...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Zheng Liu Didier Auboeuf Jiemin Wong J Don Chen Sophia Y Tsai Ming-Jer Tsai Bert W O'Malley

Selective receptor modulators, such as the antiprogestin RU486, are known to exhibit partial agonist activities in a cell-type-dependent manner. Employing an in vitro chromatin transcription system that recapitulates progesterone receptor (PR)-mediated transcription in vivo, we have investigated the molecular basis by which the antiprogestin RU486 regulates transcription in a cell-type-specific...

2012
Ping Yin Damian Roqueiro Lei Huang Jonas K. Owen Anna Xie Antonia Navarro Diana Monsivais John S. Coon V J. Julie Kim Yang Dai Serdar E. Bulun

BACKGROUND Progesterone, via its nuclear receptor (PR), exerts an overall tumorigenic effect on both uterine fibroid (leiomyoma) and breast cancer tissues, whereas the antiprogestin RU486 inhibits growth of these tissues through an unknown mechanism. Here, we determined the interaction between common or cell-specific genome-wide binding sites of PR and mRNA expression in RU486-treated uterine l...

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